DNA Methyltransferases: From Evolution to Clinical Applications
Por:
Del Castillo Falconi, Victor M., Torres-Arciga, Karla, Matus-Ortega, Genaro, Diaz-Chavez, Jose, Herrera, Luis A.
Publicada:
1 ago 2022
Resumen:
DNA methylation is an epigenetic mark that living beings have used in
different environments. The MTases family catalyzes DNA methylation.
This process is conserved from archaea to eukaryotes, from fertilization
to every stage of development, and from the early stages of cancer to
metastasis. The family of DNMTs has been classified into DNMT1, DNMT2,
and DNMT3. Each DNMT has been duplicated or deleted, having consequences
on DNMT structure and cellular function, resulting in a conserved
evolutionary reaction of DNA methylation. DNMTs are conserved in the
five kingdoms of life: bacteria, protists, fungi, plants, and animals.
The importance of DNMTs in whether methylate or not has a historical
adaptation that in mammals has been discovered in complex regulatory
mechanisms to develop another padlock to genomic insurance stability.
The regulatory mechanisms that control DNMTs expression are involved in
a diversity of cell phenotypes and are associated with pathologies
transcription deregulation. This work focused on DNA methyltransferases,
their biology, functions, and new inhibitory mechanisms reported. We
also discuss different approaches to inhibit DNMTs, the use of
non-coding RNAs and nucleoside chemical compounds in recent studies, and
their importance in biological, clinical, and industry research.
Filiaciones:
Del Castillo Falconi, Victor M.:
Inst Nacl Cancerol INCAN, Ave San Fernando 22,Secc 16 Tlalpan, Mexico City 14080, DF, Mexico
Univ Nacl Autonoma Mexico, Unidad Invest Biomed Canc, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Torres-Arciga, Karla:
Inst Nacl Cancerol INCAN, Ave San Fernando 22,Secc 16 Tlalpan, Mexico City 14080, DF, Mexico
Univ Nacl Autonoma Mexico, Unidad Invest Biomed Canc, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Matus-Ortega, Genaro:
Univ Nacl Autonoma Mexico, Dept Bioquim, Fac Med, Mexico City 04510, DF, Mexico
Diaz-Chavez, Jose:
Inst Nacl Cancerol INCAN, Ave San Fernando 22,Secc 16 Tlalpan, Mexico City 14080, DF, Mexico
Univ Nacl Autonoma Mexico, Unidad Invest Biomed Canc, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Herrera, Luis A.:
Inst Nacl Cancerol INCAN, Ave San Fernando 22,Secc 16 Tlalpan, Mexico City 14080, DF, Mexico
Univ Nacl Autonoma Mexico, Unidad Invest Biomed Canc, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Inst Nacl Med Genom, Periferico Sur 4809, Mexico City 14610, DF, Mexico
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