Type 2 diabetes, gut microbiome, and systems biology: A novel perspective for a new era
Por:
Estrella Martinez-Lopez, Yoscelina, Esquivel-Hernandez, Diego A., Paul Sanchez-Castaneda, Jean, Neri-Rosario, Daniel, Guardado-Mendoza, Rodolfo, Resendis-Antonio, Osbaldo
Publicada:
31 dic 2022
Resumen:
The association between the physio-pathological variables of type 2
diabetes (T2D) and gut microbiota composition suggests a new avenue to
track the disease and improve the outcomes of pharmacological and
non-pharmacological treatments. This enterprise requires new strategies
to elucidate the metabolic disturbances occurring in the gut microbiome
as the disease progresses. To this end, physiological knowledge and
systems biology pave the way for characterizing microbiota and
identifying strategies in a move toward healthy compositions. Here, we
dissect the recent associations between gut microbiota and T2D. In
addition, we discuss recent advances in how drugs, diet, and exercise
modulate the microbiome to favor healthy stages. Finally, we present
computational approaches for disentangling the metabolic activity
underlying host-microbiota codependence. Altogether, we envision that
the combination of physiology and computational modeling of microbiota
metabolism will drive us to optimize the diagnosis and treatment of T2D
patients in a personalized way.
Filiaciones:
Estrella Martinez-Lopez, Yoscelina:
Inst Nacl Med Genom INMEGEN, Human Syst Biol Lab, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Programa Doctorado Ciencias Med Odontol & Salud, Ciudad De Mexico, Mexico
Univ Guanajuato, Metab Res Lab, Dept Med & Nutr, Guanajuato, Mexico
Esquivel-Hernandez, Diego A.:
Inst Nacl Med Genom INMEGEN, Human Syst Biol Lab, Mexico City, DF, Mexico
Paul Sanchez-Castaneda, Jean:
Inst Nacl Med Genom INMEGEN, Human Syst Biol Lab, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Programa Maestria Ciencias Bioquim, Ciudad De Mexico, Mexico
Neri-Rosario, Daniel:
Inst Nacl Med Genom INMEGEN, Human Syst Biol Lab, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Programa Maestria Ciencias Bioquim, Ciudad De Mexico, Mexico
Guardado-Mendoza, Rodolfo:
Univ Guanajuato, Metab Res Lab, Dept Med & Nutr, Guanajuato, Mexico
Hosp Reg Alta Especialidad Bajio Leon, Res Dept, Guanajuato, Mexico
Resendis-Antonio, Osbaldo:
Inst Nacl Med Genom INMEGEN, Human Syst Biol Lab, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Coordinac Invest Cient Red Apoyo Invest, Ciudad De Mexico, Mexico
gold, All Open Access, Gold
|