HypoxaMIRs: Key Regulators of Hallmarks of Colorectal Cancer
Por:
Coronel-Hernández J., Delgado-Waldo I., Cantú De León D., López-Camarillo C., Jacobo-Herrera N., Ramos-Payán R., Pérez-Plasencia C.
Publicada:
1 ene 2022
Categoría:
Biochemistry, genetics and molecular biology (miscellaneous)
Resumen:
Hypoxia in cancer is a thoroughly studied phenomenon, and the logical cause of the reduction in oxygen tension is tumor growth itself. While sustained hypoxia leads to death by necrosis in cells, there is an exquisitely regulated mechanism that rescues hypoxic cells from their fatal fate. The accumulation in the cytoplasm of the transcription factor HIF-1a, which, under normoxic conditions, is marked for degradation by a group of oxygen-sensing proteins known as prolyl hydroxylases (PHDs) in association with the von Hippel-Lindau anti-oncogene (VHL) is critical for the cell, as it regulates different mechanisms through the genes it induces. A group of microRNAs whose expression is regulated by HIF, collectively called hypoxaMIRs, have been recognized. In this review, we deal with the hypoxaMIRs that have been shown to be expressed in colorectal cancer. Subsequently, using data mining, we analyze a panel of hypoxaMIRs expressed in both normal and tumor tissues obtained from TCGA. Finally, we assess the impact of these hypoxaMIRs on cancer hallmarks through their target genes. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Filiaciones:
Coronel-Hernández J.:
Genomics Laboratory, The National Cancer Institute of México, Tlalpan, Mexico City, 14080, Mexico
Functional Genomics Laboratory, Biomedicine Unit, FES-IZTACALA, UNAM, Tlalnepantla, 54090, Mexico
Delgado-Waldo I.:
Genomics Laboratory, The National Cancer Institute of México, Tlalpan, Mexico City, 14080, Mexico
Cantú De León D.:
Genomics Laboratory, The National Cancer Institute of México, Tlalpan, Mexico City, 14080, Mexico
López-Camarillo C.:
Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, Mexico City, 03100, Mexico
Jacobo-Herrera N.:
Biochemistry Unit, Institute of Medical Sciences and Nutrition, Salvador Zubirán, Tlalpan, Mexico City, 14080, Mexico
Ramos-Payán R.:
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Culiacan City, 80030, Mexico
Pérez-Plasencia C.:
Genomics Laboratory, The National Cancer Institute of México, Tlalpan, Mexico City, 14080, Mexico
Functional Genomics Laboratory, Biomedicine Unit, FES-IZTACALA, UNAM, Tlalnepantla, 54090, Mexico
gold, Green Published, All Open Access, Gold, Green
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