Evaluating the effect of curcumin on the metacestode of Taenia crassiceps
Por:
Martínez-González J.D.J., Ríos-Morales S.L., Guevara-Flores A., Ramos-Godinez M.D.P., López-Saavedra A., Rendón J.L., Del Arenal Mena I.P.
Publicada:
1 ene 2022
Resumen:
Curcumin, a curcuminoid present in the rhizome of the plant Curcuma longa has multiple pharmacological effects including anticarcinogenic and anti-inflammatory properties. This work evaluates the anthelmintic effect of the curcumin molecule (98% pure) on Taenia crassiceps cysticerci viability in vitro. Cysticerci incubated in the presence of increasing concentrations of curcumin showed a dose-dependent mortality correlated with a significant increase in the production of reactive oxygen species and a partial inhibition of thioredoxin-glutathione reductase, the only disulfide reductase present in these parasites. At 500 µM curcumin, a 100% of cysticerci lethality was obtained after 2 h of treatment. These results suggest the curcumin-induced oxidative stress could be in the origin of the anthelminthic effect of curcumin. Mice with cysticerci were injected intraperitoneally with 20, 40, or 60 mM curcumin daily for 30 days. A decrease in the burden of cysticerci (46%) was observed with a 60 mM dose of curcumin, supporting this compound as a potential anthelmintic drug. © 2022 Elsevier Inc.
Filiaciones:
Martínez-González J.D.J.:
Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Apartado Postal 70-159, Mexico City, 04510, Mexico
Ríos-Morales S.L.:
Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Apartado Postal 70-159, Mexico City, 04510, Mexico
Guevara-Flores A.:
Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Apartado Postal 70-159, Mexico City, 04510, Mexico
Ramos-Godinez M.D.P.:
Unidad de Aplicaciones Avanzadas en Microscopía, Instituto Nacional de Cancerología, Red de Apoyo a la Investigación (RAI), Mexico City, 14080, Mexico
López-Saavedra A.:
Unidad de Aplicaciones Avanzadas en Microscopía, Instituto Nacional de Cancerología, Red de Apoyo a la Investigación (RAI), Mexico City, 14080, Mexico
Rendón J.L.:
Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Apartado Postal 70-159, Mexico City, 04510, Mexico
Del Arenal Mena I.P.:
Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Apartado Postal 70-159, Mexico City, 04510, Mexico
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