Genomic Profile in a Non-Seminoma Testicular Germ-Cell Tumor Cohort Reveals a Potential Biomarker of Sensitivity to Platinum-Based Therapy
Por:
Gonzalez-Barrios, Rodrigo, ALCARAZ, NICOLAS, Montalvo-Casimiro, Michel, Cervera, Alejandra, Arriaga-Canon, Cristian, Munguia-Garza, Paulina, Hinojosa-Ugarte, Diego, Sobrevilla-Moreno, Nora, Torres-Arciga, Karla, Mendoza-Perez, Julia, Diaz-Chavez, Jose, Cesar Cortes-Gonzalez, Carlo, Castro-Hernandez, Clementina, Martinez-Cedillo, Jorge, Scavuzzo, Ana, Perez-Montiel, Delia, Jimenez-Rios, Miguel A., Herrera, Luis A.
Publicada:
1 may 2022
Resumen:
Despite having a favorable response to platinum-based chemotherapies,
similar to 15% of Testicular Germ-Cell Tumor (TGCT) patients are
platinum-resistant. Mortality rates among Latin American countries have
remained constant over time, which makes the study of this population of
particular interest. To gain insight into this phenomenon, we conducted
whole-exome sequencing, microarray-based comparative genomic
hybridization, and copy number analysis of 32 tumors from a Mexican
cohort, of which 18 were platinum-sensitive and 14 were
platinum-resistant. We incorporated analyses of mutational burden,
driver mutations, and SNV and CNV signatures. DNA breakpoints in genes
were also investigated and might represent an interesting research
opportunity. We observed that sensitivity to chemotherapy does not seem
to be explained by any of the mutations detected. Instead, we uncovered
CNVs, particularly amplifications on segment 2q11.1 as a novel variant
with chemosensitivity biomarker potential. Our data shed light into
understanding platinum resistance in a Latin-origin population.
Filiaciones:
Gonzalez-Barrios, Rodrigo:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Inst Invest Biomed, Unidad Invest Biomed Canc, Mexico City 14080, DF, Mexico
ALCARAZ, NICOLAS:
Univ Copenhagen, Novo Nordisk Fdn Ctr Prot Res, Fac Hlth & Med Sci, DK-2200 Copenhagen, Denmark
Inst Nacl Med Genom, Mexico City 14610, DF, Mexico
Montalvo-Casimiro, Michel:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Inst Invest Biomed, Unidad Invest Biomed Canc, Mexico City 14080, DF, Mexico
Cervera, Alejandra:
Inst Nacl Med Genom, Mexico City 14610, DF, Mexico
Arriaga-Canon, Cristian:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Inst Invest Biomed, Unidad Invest Biomed Canc, Mexico City 14080, DF, Mexico
Munguia-Garza, Paulina:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Inst Invest Biomed, Unidad Invest Biomed Canc, Mexico City 14080, DF, Mexico
Hinojosa-Ugarte, Diego:
Hosp Reg Alta Especialidad Bajio, Dept Cirugia, Leon 37660, Mexico
Sobrevilla-Moreno, Nora:
Inst Nacl Cancerol, Dept Oncol Med, Clin Tumores Genitourinarios, Mexico City 14080, DF, Mexico
Torres-Arciga, Karla:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Inst Invest Biomed, Unidad Invest Biomed Canc, Mexico City 14080, DF, Mexico
Mendoza-Perez, Julia:
Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX 77030 USA
Diaz-Chavez, Jose:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Inst Invest Biomed, Unidad Invest Biomed Canc, Mexico City 14080, DF, Mexico
Cesar Cortes-Gonzalez, Carlo:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Inst Invest Biomed, Unidad Invest Biomed Canc, Mexico City 14080, DF, Mexico
Castro-Hernandez, Clementina:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Inst Invest Biomed, Unidad Invest Biomed Canc, Mexico City 14080, DF, Mexico
Martinez-Cedillo, Jorge:
Inst Nacl Cancerol, Dept Oncol Med, Clin Tumores Genitourinarios, Mexico City 14080, DF, Mexico
Scavuzzo, Ana:
Inst Nacl Cancerol, Dept Urol, Mexico City 14080, DF, Mexico
Perez-Montiel, Delia:
Inst Nacl Cancerol, Dept Patol, Mexico City 14080, DF, Mexico
Jimenez-Rios, Miguel A.:
Inst Nacl Cancerol, Dept Urol, Mexico City 14080, DF, Mexico
Herrera, Luis A.:
Univ Nacl Autonoma Mexico, Inst Nacl Cancerol, Inst Invest Biomed, Unidad Invest Biomed Canc, Mexico City 14080, DF, Mexico
Inst Nacl Med Genom, Mexico City 14610, DF, Mexico
Green Published, gold
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