The Obese Brain: Mechanisms of Systemic and Local Inflammation, and Interventions to Reverse the Cognitive Deficit
Por:
Salas-Venegas, Veronica, Pamela Flores-Torres, Rosa, Maria Rodriguez-Cortes, Yesica, Rodriguez-Retana, Diego, Jair Ramirez-Carreto, Ricardo, Edgar Concepcion-Carrillo, Luis, Josefina Perez-Flores, Laura, Alarcon-Aguilar, Adriana, Edith Lopez-Diazguerrero, Norma, Gomez-Gonzalez, Beatriz, CHAVARRIA, ANAHI, Konigsberg, Mina
Publicada:
29 mar 2022
Resumen:
Overweight and obesity are now considered a worldwide pandemic and a
growing public health problem with severe economic and social
consequences. Adipose tissue is an organ with neuroimmune-endocrine
functions, which participates in homeostasis. So, adipocyte hypertrophy
and hyperplasia induce a state of chronic inflammation that causes
changes in the brain and induce neuroinflammation. Studies with obese
animal models and obese patients have shown a relationship between diet
and cognitive decline, especially working memory and learning
deficiencies. Here we analyze how obesity-related peripheral
inflammation can affect central nervous system physiology, generating
neuroinflammation. Given that the blood-brain barrier is an interface
between the periphery and the central nervous system, its altered
physiology in obesity may mediate the consequences on various cognitive
processes. Finally, several interventions, and the use of natural
compounds and exercise to prevent the adverse effects of obesity in the
brain are also discussed.
Filiaciones:
Salas-Venegas, Veronica:
Univ Autonoma Metropolitana, Biol Expt, Unidad Iztapalapa, Mexico City, DF, Mexico
Univ Autonoma Metropolitana Iztapalapa, Dept Ciencias Salud, Div Ciencias Biol & Salud DCBS, Mexico City, DF, Mexico
Pamela Flores-Torres, Rosa:
Univ Autonoma Metropolitana, Biol Expt, Unidad Iztapalapa, Mexico City, DF, Mexico
Univ Autonoma Metropolitana Iztapalapa, Dept Biol Reprod, DCBS, Mexico City, DF, Mexico
Maria Rodriguez-Cortes, Yesica:
Univ Nacl Autonoma Mexico, Programa Doctorado Ciencias Biomed, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Mexico City, DF, Mexico
Rodriguez-Retana, Diego:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Mexico City, DF, Mexico
Jair Ramirez-Carreto, Ricardo:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Mexico City, DF, Mexico
Edgar Concepcion-Carrillo, Luis:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Mexico City, DF, Mexico
Josefina Perez-Flores, Laura:
Univ Autonoma Metropolitana Iztapalapa, Dept Ciencias Salud, Div Ciencias Biol & Salud DCBS, Mexico City, DF, Mexico
Alarcon-Aguilar, Adriana:
Univ Autonoma Metropolitana Iztapalapa, Dept Ciencias Salud, Div Ciencias Biol & Salud DCBS, Mexico City, DF, Mexico
Edith Lopez-Diazguerrero, Norma:
Univ Autonoma Metropolitana Iztapalapa, Dept Ciencias Salud, Div Ciencias Biol & Salud DCBS, Mexico City, DF, Mexico
Gomez-Gonzalez, Beatriz:
Univ Autonoma Metropolitana Iztapalapa, Dept Biol Reprod, DCBS, Mexico City, DF, Mexico
CHAVARRIA, ANAHI:
Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Mexico City, DF, Mexico
Konigsberg, Mina:
Univ Autonoma Metropolitana Iztapalapa, Dept Ciencias Salud, Div Ciencias Biol & Salud DCBS, Mexico City, DF, Mexico
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