FACTORS ASSOCIATED WITH DEVELOPMENT OF ACUTE KIDNEY INJURY AFTER LIVER TRANSPLANTATION
Por:
CATALAN, R. O. D. R. I. G. O., JIMENEZ-CEJA, J. O. S. E. V., RINCON-PEDRERO, R. O. D. O. L. F. O., OLIVAS-MARTINEZ, A. N. T. O. N. I. O., MARTINEZ-RUEDA, A. R. M. A. N. D. O. J., BAZUA-VALENTI, S. I. L. V. A. N. A., CARRILLO-PEREZ, D. I. E. G. O. L., GRAJEDA-MEDINA, L. E. O. N. E. L. I. I., GARCIA-JUAREZ, I. G. N. A. C. I. O., VILATOBA, M. A. R. I. O., ORTEGA-TREJO, J. U. A. N. A., PEREZ-VILLALVA, R. O. S. A. L. B. A., BOBADILLA, N. O. R. M. A. A., MORENO, E. R. I. K. A., GAMBA, G. E. R. A. R. D. O.
Publicada:
1 mar 2022
Categoría:
Medicine (miscellaneous)
Resumen:
Background: Early post-liver transplant (LT) acute kidney injury (AKI)
has been associated with worse short-term and long-term outcomes, but
the incidence and risk factors in our population are unknown. Methods:
We designed a prospective, single-center, longitudinal cohort study to
determine the incidence of AKI during the immediate postoperative period
of LT, and to identify the risk factors associated with AKI after LT.
Pre-operative and intraoperative variables were analyzed to determine if
there was any correlation with the development of post-operative AKI.
Results: Eighty-six patients were included in the final analysis; from
them, 45 (52%) developed AKI in the following 30 days after LT. The
presence of hepatic encephalopathy prior to LT was the factor most
strongly associated with the development of AKI (Relative Risk 3.67,
95% Confidence Interval 1.08-8.95). Other factors associated with AKI
development were male gender and a higher serum lactate during surgery.
Conclusion: AKI was a frequent complication that significantly worsened
the prognosis of LT recipients and was associated with an increased
30-day mortality rate. The presence of hepatic encephalopathy strongly
predicted the development of severe AKI.
Filiaciones:
CATALAN, R. O. D. R. I. G. O.:
Department of Nephrology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City, Mexico
JIMENEZ-CEJA, J. O. S. E. V.:
Department of Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City, Mexico
RINCON-PEDRERO, R. O. D. O. L. F. O.:
Department of Nephrology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City, Mexico
OLIVAS-MARTINEZ, A. N. T. O. N. I. O.:
Department of Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City, Mexico
MARTINEZ-RUEDA, A. R. M. A. N. D. O. J.:
Department of Nephrology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City, Mexico
BAZUA-VALENTI, S. I. L. V. A. N. A.:
Department of Nephrology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City, Mexico
CARRILLO-PEREZ, D. I. E. G. O. L.:
Department of Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City, Mexico
GRAJEDA-MEDINA, L. E. O. N. E. L. I. I.:
Department of Nephrology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City, Mexico
GARCIA-JUAREZ, I. G. N. A. C. I. O.:
Departments of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City, Mexico
VILATOBA, M. A. R. I. O.:
Departments of Transplantation, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City, Mexico
ORTEGA-TREJO, J. U. A. N. A.:
Department of Nephrology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City, Mexico
PEREZ-VILLALVA, R. O. S. A. L. B. A.:
Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de MéxicoMexico City, Mexico
BOBADILLA, N. O. R. M. A. A.:
Department of Nephrology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City, Mexico
Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de MéxicoMexico City, Mexico
MORENO, E. R. I. K. A.:
Department of Nephrology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City, Mexico
GAMBA, G. E. R. A. R. D. O.:
Department of Nephrology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City, Mexico
Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de MéxicoMexico City, Mexico
gold, All Open Access; Gold
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