New Insights into the Mechanism of Action of PirAB from Vibrio Parahaemolyticus
Por:
Soto-Rodriguez, Sonia A., Lozano-Olvera, Rodolfo, Montfort G.R.-C., Zenteno, Edgar, Sanchez-Salgado, Jose Luis, Vibanco-Perez, Norberto, Aguilar Rendon, Karla G.
Publicada:
1 abr 2022
Resumen:
PirAB toxins secreted by Vibrio parahaemolyticus (Vp) harbor the pVA1
virulence plasmid, which causes acute hepatopancreatic necrosis disease
(AHPND), an emerging disease in Penaeid shrimp that can cause 70-100%
mortality and that has resulted in great economic losses since its first
appearance. The cytotoxic effect of PirAB(Vp) on the epithelial cells of
the shrimp hepatopancreas (Hp) has been extensively documented. New
insights into the biological role of the PirB(Vp) subunit show that it
has lectin-like activity and recognizes mucin-like O-glycosidic
structures in the shrimp Hp. The search for toxin receptors can lead to
a better understanding of the infection mechanisms of the pathogen and
the prevention of the host disease by blocking toxin-receptor
interactions using a mimetic antagonist. There is also evidence that Vp
AHPND changes the community structure of the microbiota in the
surrounding water, resulting in a significant reduction of several
bacterial taxa, especially Neptuniibacter spp. Considering these
findings, the PirAB(vp) toxin could exhibit a dual role of damaging the
shrimp Hp while killing the surrounding bacteria.
Filiaciones:
Laboratorio de Bacteriología, Centro de Investigación en Alimentación y Desarrollo, A.C. Unidad de Acuacultura y Manejo Ambiental, Av. Sábalo-Cerritos S/N A.P. 711, Sinaloa, Mazatlán, 82112, Mexico
Centro de Investigación en Alimentación y Desarrollo A.C, Carretera Gustavo Enrique Astiazarán Rosas, No. 46, Col. La Victoria, Sonora, Hermosillo, 83304, Mexico
Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacan, Mexico City, 04510, Mexico
Laboratorio de Investigación en Biología Molecular e Inmunología, Unidad Académica de Ciencias Químico Biológicas y Farmacéuticas, Universidad Autónoma de Nayarit, Nayarit, Ciudad de la Cultura, Tepic, 63190, Mexico
Green Published, gold, All Open Access; Gold
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