Seroconversion dynamic and SARS-CoV-2 seropositivity in unvaccinated population during the first and second outbreaks in Mexico
Por:
Fernandez-Rojas, Miguel A., Luna-Ruiz Esparza, Marco A., Campos-Romero, Abraham, Calva-Espinosa, Diana Y., Moreno-Camacho, Jose L., Mendlovic, Fela, Plett-Torres, Tanya, Alcantar-Fernandez, Jonathan
Publicada:
28 mar 2022
Categoría:
Multidisciplinary
Resumen:
Serosurveillance helps establish reopening guidelines and determine the
immunity levels in different populations to reach herd immunity. Then,
there is an urgent need to estimate seroprevalence population wide. In
Mexico, information about COVID-19 cases and related deaths is scarce.
Also, there is no official serosurveillance, limiting our knowledge of
the impact of the SARS-CoV-2 pandemic. Here, we report the prevalence of
anti-SARS-CoV-2 antibodies in 522,690 unvaccinated people from July 5th
to December 31st, 2020. The overall seroprevalence was 32.8% and
highest in adults aged 30-39 years (38.5%) than people under 20 years
(33.0%) or older (28.9%). Moreover, in a cohort of 1655 individuals
confirmed COVID-19 by PCR, we found that symptomatic people (HR = 2.56)
increased seroconversion than presymptomatic. Also, we identified that
the most discriminative symptoms for COVID-19 that could predict
seroconversion were anosmia and ageusia (HR = 1.70), fever,
myalgia/arthralgia, and cough (HR = 1.75). Finally, we found that obese
people had lower seroconversion (HR = 0.53) than healthy people, but the
opposite happens in diabetic people (HR = 1.39). These findings reveal
that around one-third of Mexican outpatients had anti-SARS-CoV-2
antibodies before vaccination. Also, some symptoms improve empirically
COVID-19 diagnosis and seroconversion. This information could help
fine-tune vaccination schemes and the reopening and back-to-work
algorithms.
Filiaciones:
Fernandez-Rojas, Miguel A.:
Salud Digna AC, Innovat & Res Dept, Francisco Villa 113 Sur, Culiacan 80000, Sinaloa, Mexico
Luna-Ruiz Esparza, Marco A.:
Salud Digna AC, Innovat & Res Dept, Francisco Villa 113 Sur, Culiacan 80000, Sinaloa, Mexico
Campos-Romero, Abraham:
Salud Digna AC, Innovat & Res Dept, Francisco Villa 113 Sur, Culiacan 80000, Sinaloa, Mexico
Calva-Espinosa, Diana Y.:
Salud Digna, Clin Lab Dept, Culiacan 80000, Sinaloa, Mexico
Moreno-Camacho, Jose L.:
Salud Digna, Clin Lab Dept, Culiacan 80000, Sinaloa, Mexico
Salud Digna, Natl Reference Ctr Culiacan, Culiacan 80300, Sinaloa, Mexico
Mendlovic, Fela:
Univ Nacl Autonoma Mexico, Dept Microbiol & Parasitol, Fac Med, Mexico City, DF, Mexico
Univ Anahuac Mexico Norte, Fac Ciencias Salud, Huixquilucan, Estado De Mexic, Mexico
Plett-Torres, Tanya:
Univ Nacl Autonoma Mexico, Plan Estudios Combinados Med, Fac Med, Mexico City, DF, Mexico
Alcantar-Fernandez, Jonathan:
Salud Digna AC, Innovat & Res Dept, Francisco Villa 113 Sur, Culiacan 80000, Sinaloa, Mexico
Green Published, gold, Gold, Green
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