Contribution of APOA5, APOC3, CETP, ABCA1 and SIK3 genetic variants to hypertriglyceridemia development in Mexican HIV-patients receiving antiretroviral therapy
Por:
Saul Bautista-Martinez, Jonathan, Antonio Mata-Marin, Jose, Luis Sandoval-Ramirez, Jorge, Chaparro-Sanchez, Alberto, Manjarrez-Tellez, Bulmaro, Antonio Uribe-Noguez, Luis, Gaytan-Martinez, Jesus, Nunez-Armendariz, Mireya, Cruz-Sanchez, Arcenio, Nunez-Rodriguez, Nohemi, Ivan, Martinez-Abarca, Selene Morales-Gonzalez, Georgina, Pablo Alvarez-Mendoza, Juan, Perez-Barragan, Edgar, Rios-De Los Rios, Jussara, Gabriel Contreras-Chavez, Gerson, Marielle Tapia-Magallanes, Denisse, Maria Ribas-Aparicio, Rosa, Diaz-Lopez, Monica, Olivares-Labastida, Azucena, Gomez-Delgado, Alejandro, Torres, Javier, Miranda-Duarte, Antonio, Zenteno, Juan C., Nelly Pompa-Mera, Ericka
Publicada:
1 abr 2022
Resumen:
Objective To investigate the impact of single nucleotide polymorphisms
(SNPs) from APOA5, APOC3, CETP, ATP binding cassette transporter A1 and
SIK3 genes in the development of hypertriglyceridemia in HIV patients
under antiretroviral therapy. Material and Methods A case-control study
was developed. Leukocytic genomic DNA was extracted and genotyping for
SNPs rs662799, rs964184, rs5128, rs2854116, rs2854117, rs3764261,
rs4149310, rs4149267 and rs139961185 was performed by real time-PCR
using TaqMan allelic discrimination assays, in Mexican mestizo patients
with HIV infection, with hypertriglyceridemia (>1.7 mmol/L) under
antiretroviral therapy. Genetic variants were also investigated in a
control group of normolipidemic HIV patients (<= 1.7 mmol/L). Haplotypes
and gene interactions were analyzed. Results A total of 602 HIV patients
were genotyped (316 cases and 286 controls). Age and antiretroviral
regimen based on protease inhibitors were associated with
hypertriglyceridemia (P = 0.0001 and P = 0.0002. respectively). SNP
rs964184 GG genotype in APOA5 gene exhibited the highest association
with hypertriglyceridemia risk (OR, 3.2, 95% CI, 1.7-5.8, P = 0.0001);
followed by SNP rs139961185 in SIK3 gene (OR = 2.3; (95% CI, 1.1-4.8; P
= 0.03 for AA vs. AG genotype; and APOC3 rs5128 GG genotype, (OR, 2.2;
95% CI, 1.1-4.9; P = 0.04) under codominant models. These associations
were maintained in the adjusted analysis by age and protease inhibitors
based antiretroviral regimens. Conclusions This study reveals an
association between rs964184 in APOA5; rs5128 in APOC3 and rs139961185
in SIK3 and high triglyceride concentrations in Mexican HIV-patients
receiving protease inhibitors. These genetic factors may influence the
adverse effects related to antiretroviral therapy.
Filiaciones:
Saul Bautista-Martinez, Jonathan:
UMAE Hosp Pediat, Ctr Med Nacl Siglo XXI, Unidad Invest Med Enfermedades Infecciosas & Para, Inst Mexicano Seguro Social,IMSS, Av Cuauhtemoc 330, Mexico City 06720, DF, Mexico
Inst Politecn Nacl, Dept Microbiol, Escuela Nacl Ciencias Biol, Mexico City, DF, Mexico
Antonio Mata-Marin, Jose:
Hosp Infectol, Ctr Med Nacl La Raza, Serv Infectol Adultos, Mexico City, DF, Mexico
Luis Sandoval-Ramirez, Jorge:
Hosp Infectol, Ctr Med Nacl La Raza, Serv Infectol Adultos, Mexico City, DF, Mexico
Chaparro-Sanchez, Alberto:
Hosp Infectol, Ctr Med Nacl La Raza, Serv Infectol Adultos, Mexico City, DF, Mexico
Manjarrez-Tellez, Bulmaro:
Hosp Infectol, Ctr Med Nacl La Raza, Serv Infectol Adultos, Mexico City, DF, Mexico
Antonio Uribe-Noguez, Luis:
Hosp Infectol, Ctr Med Nacl La Raza, Serv Infectol Adultos, Mexico City, DF, Mexico
Gaytan-Martinez, Jesus:
Hosp Infectol, Ctr Med Nacl La Raza, Serv Infectol Adultos, Mexico City, DF, Mexico
Nunez-Armendariz, Mireya:
Hosp Gen Zona 27, Inst Mexicano Seguro Social, Mexico City, DF, Mexico
Cruz-Sanchez, Arcenio:
Hosp Gen Zona 27, Inst Mexicano Seguro Social, Mexico City, DF, Mexico
Nunez-Rodriguez, Nohemi:
Hosp Gen Zona 24, Inst Mexicano Seguro Social, IMSS, Mexico City, DF, Mexico
Ivan, Martinez-Abarca:
Hosp Gen Reg 72, Inst Mexicano Seguro Social, IMSS, Tlalnepantla, Estado De Mexic, Mexico
Selene Morales-Gonzalez, Georgina:
Hosp Gen Zona 1, Inst Mexicano Seguro Social, Clin VIH, Mexico City, DF, Mexico
Pablo Alvarez-Mendoza, Juan:
Hosp Gen Zona 1, Inst Mexicano Seguro Social, Clin VIH, Mexico City, DF, Mexico
Perez-Barragan, Edgar:
Hosp Gen Zona 48, Inst Mexicano Seguro Social, IMSS, Mexico City, DF, Mexico
Rios-De Los Rios, Jussara:
UMAE Hosp Pediat, Ctr Med Nacl Siglo XXI, Unidad Invest Med Enfermedades Infecciosas & Para, Inst Mexicano Seguro Social,IMSS, Av Cuauhtemoc 330, Mexico City 06720, DF, Mexico
Gabriel Contreras-Chavez, Gerson:
UMAE Hosp Pediat, Ctr Med Nacl Siglo XXI, Unidad Invest Med Enfermedades Infecciosas & Para, Inst Mexicano Seguro Social,IMSS, Av Cuauhtemoc 330, Mexico City 06720, DF, Mexico
Marielle Tapia-Magallanes, Denisse:
UMAE Hosp Pediat, Ctr Med Nacl Siglo XXI, Unidad Invest Med Enfermedades Infecciosas & Para, Inst Mexicano Seguro Social,IMSS, Av Cuauhtemoc 330, Mexico City 06720, DF, Mexico
Maria Ribas-Aparicio, Rosa:
Inst Politecn Nacl, Dept Microbiol, Escuela Nacl Ciencias Biol, Mexico City, DF, Mexico
Diaz-Lopez, Monica:
UMAE Hosp Pediat, Ctr Med Nacl Siglo XXI, Unidad Invest Med Enfermedades Infecciosas & Para, Inst Mexicano Seguro Social,IMSS, Av Cuauhtemoc 330, Mexico City 06720, DF, Mexico
Inst Politecn Nacl, Dept Microbiol, Escuela Nacl Ciencias Biol, Mexico City, DF, Mexico
Olivares-Labastida, Azucena:
UMAE Hosp Pediat, Ctr Med Nacl Siglo XXI, Unidad Invest Med Enfermedades Infecciosas & Para, Inst Mexicano Seguro Social,IMSS, Av Cuauhtemoc 330, Mexico City 06720, DF, Mexico
Inst Politecn Nacl, Dept Microbiol, Escuela Nacl Ciencias Biol, Mexico City, DF, Mexico
Gomez-Delgado, Alejandro:
UMAE Hosp Pediat, Ctr Med Nacl Siglo XXI, Unidad Invest Med Enfermedades Infecciosas & Para, Inst Mexicano Seguro Social,IMSS, Av Cuauhtemoc 330, Mexico City 06720, DF, Mexico
Torres, Javier:
UMAE Hosp Pediat, Ctr Med Nacl Siglo XXI, Unidad Invest Med Enfermedades Infecciosas & Para, Inst Mexicano Seguro Social,IMSS, Av Cuauhtemoc 330, Mexico City 06720, DF, Mexico
Miranda-Duarte, Antonio:
Inst Nacl Rehabil Luis Guillermo Ibarra Ibarra, Dept Med Genom, Mexico City, DF, Mexico
Zenteno, Juan C.:
Inst Ophthalmol Conde Valenciana, Dept Genet, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Dept Biochem, Mexico City, DF, Mexico
Nelly Pompa-Mera, Ericka:
UMAE Hosp Pediat, Ctr Med Nacl Siglo XXI, Unidad Invest Med Enfermedades Infecciosas & Para, Inst Mexicano Seguro Social,IMSS, Av Cuauhtemoc 330, Mexico City 06720, DF, Mexico
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