lncRNAs in mesenchymal differentiation
Por:
De la Fuente-Hernandez M.A., Sarabia-Sanchez M.A., Melendez-Zajgla, Jorge, Maldonado-Lagunas, Vilma
Publicada:
1 ene 2022
Resumen:
In recent years, technological advances have revealed a large potential number of long noncoding RNAs (lncRNAs). Findings recognize lncRNAs as orchestrating molecules in a wide range of processes, at the transcriptional and posttranscriptional levels, although fewer studies address function. For differentiation, which consists of rearrangements in the gene expression profile and activation of stage- and cell type-dependent signaling mechanisms, the relevance of lncRNAs becomes crucial. The relationship between lncRNAs and key molecular factors in differentiation is strengthening; therefore the present review aims to comprehensively explain the role of lncRNAs in the signaling network involved in the main types of mesenchymal differentiation: adipogenesis, chondrogenesis, myogenesis, and osteogenesis. Notably, a step toward the integration of lncRNAs in the field of cell differentiation promises an exceptional impact.
Filiaciones:
De la Fuente-Hernandez M.A.:
Posgrado en Ciencias Biológicas, Facultad de Medicina, Universidad Nacional Autónoma de MéxicoMexico City, Mexico
Laboratorio de Epigenética, Instituto Nacional de Medicina GenómicaMexico City, Mexico
Sarabia-Sanchez M.A.:
Posgrado en Ciencias Bioquímicas, Facultad de Medicina, Universidad Nacional Autónoma de MéxicoMexico City, Mexico
Melendez-Zajgla, Jorge:
Laboratorio de Genómica Funcional del Cáncer, Instituto Nacional de Medicina GenómicaMexico City, Mexico
Maldonado-Lagunas, Vilma:
Laboratorio de Epigenética, Instituto Nacional de Medicina GenómicaMexico City, Mexico
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