A preoperative nomogram for predicting long-term survival after resection of large hepatocellular carcinoma (>10 cm)
Por:
Ruiz, Eloy, Pineau, Pascal, Flores, Claudio, Fernandez, Ramiro, Cano, Luis, Cerapio, Juan Pablo, Casavilca-Zambrano, Sandro, Berrospi, Francisco, Chavez, Ivan, Roche, Benjamin, Bertani, Stephane
Publicada:
1 feb 2022
Resumen:
Background: It has previously been demonstrated that a fraction of
patients with hepatocellular carcinoma (HCC) > 10 cm can benefit from
liver resection. However, there is still a lack of effective decision
making tools to inform intervention in these patients. Methods: We
analysed a comprehensive set of clinical data from 234 patients who
underwent liver resection for HCC >10 cm at the National Cancer
Institute of Peru between 1990 and 2015, monitored their survival, and
constructed a nomogram to predict the surgical outcome based on
preoperative variables. Results: We identified cirrhosis, multifocality,
macroscopic vascular invasion, and spontaneous tumour rupture as
independent predictors of survival and integrated them into a nomogram
model. The nomogram's ability to forecast survival at 1, 3, and 5 years
was subsequently confirmed with high concordance using an internal
validation. Through applying this nomogram, we stratified three groups
of patients with different survival probabilities. Conclusion: We
constructed a preoperative nomogram to predict long-term survival in
patients with HCC >10 cm. This nomogram is useful in determining whether
a patient with large HCC might truly benefit from liver resection, which
is paramount in low-and middle-income countries where HCC is often
diagnosed at advanced stages.
Filiaciones:
Ruiz, Eloy:
Departamento de Cirugía en Abdomen, Instituto Nacional de Enfermedades Neoplásicas (INEN), Lima, Peru
Pineau, Pascal:
Unité Organisation Nucléaire et Oncogenèse, INSERM, Institut Pasteur, Paris, France
Flores, Claudio:
Unidad de Investigación Básica y Traslacional, Oncosalud-AUNA, Lima, Peru
Fernandez, Ramiro:
Departamento de Cirugía en Abdomen, Instituto Nacional de Enfermedades Neoplásicas (INEN), Lima, Peru
Cano, Luis:
UMR 1241 NUMECAN, Université de Rennes, INSERM, Rennes, France
Cerapio, Juan Pablo:
UMR 1037 CRCT, Université de Toulouse, INSERM, Toulouse, France
Casavilca-Zambrano, Sandro:
Departamento de Patología, Instituto Nacional de Enfermedades Neoplásicas (INEN), Lima, Peru
Berrospi, Francisco:
Departamento de Cirugía en Abdomen, Instituto Nacional de Enfermedades Neoplásicas (INEN), Lima, Peru
Chavez, Ivan:
Departamento de Cirugía en Abdomen, Instituto Nacional de Enfermedades Neoplásicas (INEN), Lima, Peru
Roche, Benjamin:
Centre de Recherches Écologiques & Évolutives sur le Cancer (CREEC), Université de Montpellier, CNRS, IRD, Montpellier, France
UMR 5290 MIVEGEC, IRD, CNRS, Université de Montpellier, Montpellier, France
Departamento de Etología, Fauna Silvestre y Animales de Laboratorio, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico
Bertani, Stephane:
UMR 152 PHARMADEV, Université de Toulouse, IRD, Toulouse, France
hybrid, Green Published, All Open Access, Hybrid Gold, Green
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