Comparative analysis of two hydrogel architectures synthesized by gamma radiation based on dimethylacrylamide and acrylic acid grafted on polyethylene
Por:
Valencia-May, E. G., Rivera, E., Novelo-Peralta, O., Burillo, G.
Publicada:
1 may 2022
Categoría:
Radiation
Resumen:
This study reports the synthesis of new modified polymeric systems that
could be applied to the upload and delivery of drugs using gamma
radiation. It is known that different architectures with the same
components results in different properties, and it is therefore of
interest to compare them. Two different systems were prepared using a
polyethylene (PE) matrix grafted with a comb-type hydrogel based on N,
N-dimethylacrylamide (DMAAm) and acrylic acid (AAc) and one
interpenetrating network of the same monomers. First, PE was grafted
onto DMAAm using gamma radiation under different reaction conditions,
which involved changes in the absorbed dose, solvents, and
concentration. Second, a crosslinked hydrogel network of DMAAm grafted
onto a PE film surface was obtained by gamma radiation and subsequently
modified with AAc to form two different architectures: a comb-type graft
[PE-g-(net-DMAAm)]-comb-AAc and an interpenetrating network grafted
onto PE, PE-g-[(net-DMAAm)-inter-(net-AAc)]. To evaluate the effect of
the grafting reaction on the hydrophilicity, swelling studies were
performed and the critical pH values were determined. The obtained
systems were characterized by Fourier-transform infrared spectroscopy
(FTIR), X-ray Diffraction (XRD), Differential scanning calorimetry
(DSC), Thermogravimetric analysis (TGA), mechanical properties, and
Scanning Electron Microscopy (SEM). Comparison between the properties of
both systems was done.
Filiaciones:
Valencia-May, E. G.:
Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Ciudad de México, 04510, Mexico
Univ Nacl Autonoma Mexico, Inst Ciencias Nucl, Ciudad De Mexico 04510, Mexico
Rivera, E.:
Instituto de Investigaciones en Materiales, Ciudad Universitaria, Ciudad de México, 04510, Mexico
Inst Invest Mat, Ciudad De Mexico 04510, Mexico
Novelo-Peralta, O.:
Instituto de Investigaciones en Materiales, Ciudad Universitaria, Ciudad de México, 04510, Mexico
Inst Invest Mat, Ciudad De Mexico 04510, Mexico
Burillo, G.:
Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Ciudad de México, 04510, Mexico
(Corresponding Author), Univ Nacl Autonoma Mexico, Inst Ciencias Nucl, Ciudad De Mexico 04510, Mexico
Univ Nacl Autonoma Mexico, Inst Ciencias Nucl, Ciudad De Mexico 04510, Mexico
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