Zinc associated nanomaterials and their intervention in emerging respiratory viruses: Journey to the field of biomedicine and biomaterials
Por:
Gutiérrez Rodelo C., Salinas R.A., Armenta JaimeArmenta E., Armenta S., Galdámez-Martínez A., Castillo-Blum S.E., Astudillo-de la Vega H., Nirmala Grace A., Aguilar-Salinas C.A., Gutiérrez Rodelo J., Christie G., Alsanie W.F., Santana G., Thakur V.K., Dutt A.
Publicada:
1 ene 2022
Resumen:
Respiratory viruses represent a severe public health risk worldwide, and the research contribution to tackle the current pandemic caused by the SARS-CoV-2 is one of the main targets among the scientific community. In this regard, experts from different fields have gathered to confront this catastrophic pandemic. This review illustrates how nanotechnology intervention could be valuable in solving this difficult situation, and the state of the art of Zn-based nanostructures are discussed in detail. For virus detection, learning from the experience of other respiratory viruses such as influenza, the potential use of Zn nanomaterials as suitable sensing platforms to recognize the S1 spike protein in SARS-CoV-2 are shown. Furthermore, a discussion about the antiviral mechanisms reported for ZnO nanostructures is included, which can help develop surface disinfectants and protective coatings. At the same time, the properties of Zn-based materials as supplements for reducing viral activity and the recovery of infected patients are illustrated. Within the scope of noble adjuvants to improve the immune response, the ZnO NPs properties as immunomodulators are explained, and potential prototypes of nanoengineered particles with metallic cations (like Zn2+) are suggested. Therefore, using Zn-associated nanomaterials from detection to disinfection, supplementation, and immunomodulation opens a wide area of opportunities to combat these emerging respiratory viruses. Finally, the attractive properties of these nanomaterials can be extrapolated to new clinical challenges. © 2022 The Authors
Filiaciones:
Gutiérrez Rodelo C.:
Healthcare Business and Computer Technology, Mexico
Nanopharmacia Diagnostica, Tlaxcala No. 146/705, Col. Roma Sur, Cuauhtémoc, Cuidad de México, C.P. 06760, Mexico
Salinas R.A.:
Centro de Investigación en Biotecnología Aplicada del Instituto Politécnico Nacional (CIBA-IPN), Tlaxcala, 72197, Mexico
Armenta JaimeArmenta E.:
Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, DF 04510, Mexico
Armenta S.:
Department of Biology, McGill University, 3649 Sir William Osler, Montreal, QC H3G 0B1, Canada
Galdámez-Martínez A.:
Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Coyoacán, México City, C.P. 04510, Mexico
Castillo-Blum S.E.:
Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, DF 04510, Mexico
Astudillo-de la Vega H.:
Healthcare Business and Computer Technology, Mexico
Nanopharmacia Diagnostica, Tlaxcala No. 146/705, Col. Roma Sur, Cuauhtémoc, Cuidad de México, C.P. 06760, Mexico
Nirmala Grace A.:
Centre for Nanotechnology Research, VIT University, Vellore, Tamil Nadu 632 014, India
Aguilar-Salinas C.A.:
Unidad de Investigación de Enfermedades Metabólicas y Dirección de Nutrición. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico
Gutiérrez Rodelo J.:
Instituto Méxicano del Seguro Social, Hospital General de SubZona No. 4, C.P. 80370, Navolato, Sinaloa, Mexico
Christie G.:
Institute of Biotechnology, Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK CB2 1QT, United Kingdom
Alsanie W.F.:
Department of Clinical Laboratories Sciences, The Faculty of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia
Santana G.:
Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Coyoacán, México City, C.P. 04510, Mexico
Thakur V.K.:
Biorefining and Advanced Materials Research Center, SRUC, Edinburgh, UK EH9 3JG, United Kingdom
Department of Mechanical Engineering, School of Engineering, Shiv Nadar UniversityUttar Pradesh 201314, India
School of Engineering, University of Petroleum & Energy Studies (UPES), Dehradun, Uttarakhand 248007, India
Dutt A.:
Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Coyoacán, México City, C.P. 04510, Mexico
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