Experimental and theoretical studies of pegylated-beta-cyclodextrin: A step forward to understand its tunable self-aggregation abilities
Por:
Rincon-Lopez, Juliana, Ramirez-Rodriguez, Norma J., Luviano, Alberto S., Costas, Miguel, Lopez-Cervantes, Jose L., Garcia-Figueroa, Arturo A., Dominguez, Hector, Mendoza-Cruz, Ruben, Guadarrama, Patricia, Lopez-Morales, Salvador, Rojas-Aguirre, Yareli
Publicada:
1 ene 2022
Categoría:
Pharmaceutical science
Resumen:
In this work we studied the self-aggregation abilities of beta CDPEG5, a
star-shaped pegylated derivative comprising seven PEG chains selectively
conjugated to the primary face of pap via triazole linkers. The critical
aggregation concentration, determined by density measurements, yielded a
value of 0.5 mM. Dynamic light scattering (DLS) showed that beta CDPEG5
forms nanoaggregates of a hydrodynamic diameter (Dh) of similar to 150
nm in water at 25 degrees C. beta CDPEG5 significantly decreased the
surface tension of water, thus confirming the aggregation phenomenon.
Transmission electron microscopy upheld the presence of the
nanoaggregates and revealed their quasi-spherical shape. Nanostructures
of 9 nm coexisting with the nanoaggregates were also observed in DLS and
correspond to beta CDPEG5 dimers. Computational studies analyzed dimers
as the initial stage in the beta CDPEG5 nanoaggregation process.
Both beta CDPEG5 nanoaggregates and dimers displayed their same Dh
pattern in acidic, neutral, and basic conditions; likewise, when
modifying the ionic strength of the medium. Interestingly, the
nanoaggregates and dimers varied depending on the experimental
conditions, being the former predominant when increasing pH and ionic
strength, a behavior attributed to the triazole linkers, which seem to
respond smartly to changes in the environment. At 37 degrees C, only
beta CDPEG5 nanoaggregates were present with a Dh mean value similar to
that at 25 degrees C. The scattering behavior of nanoaggregates and
dimers was studied for 55 days. We found that Dh of both species remains
unchanged; nevertheless, at the end of the analysis, the nanoaggregates
population was predominant.
These overall results demonstrate that beta CDPEG5 is an amphiphilic
non-ionic system with a remarkable ability to aggregate in water and
form defined nanostructures. Moreover, depending on the beta CDPEG5
concentration, pH, ionic strength, and temperature, the dimeric or
nanoaggregated state can be tuned, being this an attractive feature to
load and control the release of a drug.
Filiaciones:
Rincon-Lopez, Juliana:
Laboratorio de Materiales Supramoleculares (SupraMatLab), Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria, Mexico City, 04510, Mexico
Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Ciudad Universitaria, México City, 04510, Mexico
Ramirez-Rodriguez, Norma J.:
Laboratorio de Materiales Supramoleculares (SupraMatLab), Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria, Mexico City, 04510, Mexico
Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Ciudad Universitaria, México City, 04510, Mexico
Luviano, Alberto S.:
Laboratorio de Bio?sicoquímica, Departamento de Fisicoquímica, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico
Costas, Miguel:
Laboratorio de Bio?sicoquímica, Departamento de Fisicoquímica, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico
Lopez-Cervantes, Jose L.:
Laboratorio de Superficies, Departamento de Fisicoquímica, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico
Garcia-Figueroa, Arturo A.:
Laboratorio de Superficies, Departamento de Fisicoquímica, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, 04510, Mexico
Dominguez, Hector:
Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Ciudad Universitaria, México City, 04510, Mexico
Mendoza-Cruz, Ruben:
Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Ciudad Universitaria, México City, 04510, Mexico
Guadarrama, Patricia:
Laboratorio de Materiales Supramoleculares (SupraMatLab), Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria, Mexico City, 04510, Mexico
Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Ciudad Universitaria, México City, 04510, Mexico
Lopez-Morales, Salvador:
Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Ciudad Universitaria, México City, 04510, Mexico
Rojas-Aguirre, Yareli:
Laboratorio de Materiales Supramoleculares (SupraMatLab), Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria, Mexico City, 04510, Mexico
Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Ciudad Universitaria, México City, 04510, Mexico
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