Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways
Por:
Chairez-Ramirez, Manuel Humberto, de la Cruz-lopez, Karen Griselda, Garcia-Carranca, Alejandro
Publicada:
20 oct 2021
Resumen:
Polyphenols constitute an important group of natural products that are
traditionally associated with a wide range of bioactivities. These are
usually found in low concentrations in natural products and are now
available in nutraceuticals or dietary supplements. A group of
polyphenols that include apigenin, quercetin, curcumin, resveratrol,
EGCG, and kaempferol have been shown to regulate signaling pathways that
are central for cancer development, progression, and metastasis. Here,
we describe novel mechanistic insights on the effect of this group of
polyphenols on key elements of the signaling pathways impacting cancer.
We describe the protein modifications induced by these polyphenols and
their effect on the central elements of several signaling pathways
including PI3K, Akt, mTOR, RAS, and MAPK and particularly those
affecting the tumor suppressor p53 protein. Modifications of p53 induced
by these polyphenols regulate p53 gene expression and protein levels and
posttranslational modifications such as phosphorylation, acetylation,
and ubiquitination that influence stability, subcellular location,
activation of new transcriptional targets, and the role of p53 in
response to DNA damage, apoptosis control, cell- cycle regulation,
senescence, and cell fate. Thus, deep understanding of the effects that
polyphenols have on these key players in cancer-driving signaling
pathways will certainly lead to better designed targeted therapies, with
less toxicity for cancer treatment. The scope of this review centers on
the regulation of key elements of cancer signaling pathways by the most
studied polyphenols and highlights the importance of a profound
understanding of these regulations in order to improve cancer treatment
and control with natural products.
Filiaciones:
Chairez-Ramirez, Manuel Humberto:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Unidad Invest Biomed Canc, Mexico City, DF, Mexico
Inst Nacl Cancerol, Secretaria Salud, Mexico City, DF, Mexico
de la Cruz-lopez, Karen Griselda:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Unidad Invest Biomed Canc, Mexico City, DF, Mexico
Inst Nacl Cancerol, Secretaria Salud, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Programa Doctorado Ciencias Biomed, Mexico City, DF, Mexico
Garcia-Carranca, Alejandro:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Unidad Invest Biomed Canc, Mexico City, DF, Mexico
Inst Nacl Cancerol, Secretaria Salud, Mexico City, DF, Mexico
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