On the Biomedical Properties of Endocannabinoid Degradation and Reuptake Inhibitors: Pre-clinical and Clinical Evidence
Por:
Paredes-Ruiz, Karen Jaqueline, Chavira-Ramos, Karla, Orozco-Morales, Mario, Karasu, Cimen, Tinkov, Alexey A., Aschner, Michael, SANTAMARIA, ABEL, Colin-Gonzalez, Ana Laura
Publicada:
1 dic 2021
Resumen:
The endocannabinoid system (ECS) is composed of endogenous cannabinoids;
components involved in their synthesis, transport, and degradation; and
an expansive variety of cannabinoid receptors. Hypofunction or
deregulation of the ECS is related to pathological conditions.
Consequently, endogenous enhancement of endocannabinoid levels and/or
regulation of their metabolism represent promising therapeutic
approaches. Several major strategies have been suggested for the
modulation of the ECS: (1) blocking endocannabinoids degradation, (2)
inhibition of endocannabinoid cellular uptake, and (3) pharmacological
modulation of cannabinoid receptors as potential therapeutic targets.
Here, we focused in this review on degradation/reuptake inhibitors over
cannabinoid receptor modulators in order to provide an updated synopsis
of contemporary evidence advancing mechanisms of endocannabinoids as
pharmacological tools with therapeutic properties for the treatment of
several disorders. For this purpose, we revisited the available
literature and reported the latest advances regarding the biomedical
properties of fatty acid amide hydrolase and monoacylglycerol lipase
inhibitors in pre-clinical and clinical studies. We also highlighted
anandamide and 2-arachidonoylglycerol reuptake inhibitors with promising
results in pre-clinical studies using in vitro and animal models as an
outlook for future research in clinical trials.
Filiaciones:
Univ Nacl Autonoma Mexico, Fac Ciencias, Mexico City, DF, Mexico
Inst Nacl Neurol & Neurocirug, Lab Neurofarmacol Mol & Nanotecnol, Lab Aminoacidos Excitadores, SSA Insurgentes Sur 3877, Mexico City 14269, DF, Mexico
Inst Nacl Cancerol, Unidad Func Oncol Torac, Mexico City, DF, Mexico
Inst Nacl Cancerol, Lab Med Personalizada, Mexico City, DF, Mexico
Gazi Univ, Fac Med, Cellular Stress Response & Signal Transduct Res L, Dept Med Pharmacol, Ankara, Turkey
IM Sechenov First Moscow State Med Univ Sechenov, Moscow, Russia
Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10467 USA
Inst Nacl Cancerol, Lab Clin, Mexico City, DF, Mexico
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