Field study on the determination of the effective dose of injectable fosfatriclaben prodrug in sheep naturally infected with Fasciola hepatica
Por:
Ibarra-Velarde, Froylan, Rojas-Campos, Tania, Vera-Montenegro, Yolanda, Flores-Ramos, Miguel, CASTILLO, RAFAEL, Leyva-Gomez, Gerardo
Publicada:
1 ene 2022
Resumen:
The aim of the present study was to determine the effective dose of
fosfatriclaben through a field study in sheep naturally infected with F.
hepatica. Thirty crossbred sheep positive for fluke eggs were selected
for inclusion in the trial. On day 0, 5 groups of 6 animals each were
formed for treatments: group 1 (G1), G2, and G3 received fosfatriclaben
at 4, 6, and 8 mg/kg/IM, respectively. G4 received triclabendazole at 10
mg/kg/PO, and G5 was the untreated control group. Fecal samples of the
sheep were analyzed to count the number of fluke eggs to evaluate the
percentage of egg reduction. Twenty-one days after treatment, all sheep
were humanely euthanized to extract the flukes from the bile ducts. They
were counted to assess the percentage of fluke reduction. Fosfatriclaben
reduced fluke eggs by 99.6, 99.6, and 100% and flukes by 94.3, 100, and
100%, respectively. Triclabendazole reduced fluke eggs by 95.2% and
flukes by 100%. The fosfatriclaben injectable prodrug showed a high
fasciolicidal efficacy similar to triclabendazole, with advantages over
its predecessor, since only half the dose as compared to triclabendazole
was required to remove eggs and flukes in the sheep that were studied.
Filiaciones:
Ibarra-Velarde, Froylan:
Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Dept Parasitol, Ciudad De Mexico 04510, Mexico
Rojas-Campos, Tania:
Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Dept Parasitol, Ciudad De Mexico 04510, Mexico
Vera-Montenegro, Yolanda:
Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Dept Parasitol, Ciudad De Mexico 04510, Mexico
Flores-Ramos, Miguel:
Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Dept Parasitol, Ciudad De Mexico 04510, Mexico
Univ Nacl Autonoma Mexico, Unidad Merida, Escuela Nacl Estudios Super, Carretera Merida Tetiz Km 4, Ucu 97357, Yucatan, Mexico
CASTILLO, RAFAEL:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Ciudad De Mexico 04510, Mexico
Leyva-Gomez, Gerardo:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Ciudad De Mexico 04510, Mexico
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