Encapsulation of Asparaginase as a Promising Strategy to Improve In Vivo Drug Performance
Por:
Villanueva-Flores, Francisca, Zarate-Romero, Andres, Torres, Alfredo G., Huerta-Saquero, Alejandro
Publicada:
1 nov 2021
Categoría:
Pharmaceutical science
Resumen:
Asparaginase (ASNase) is a widely applied chemotherapeutic drug that is
used to treat Acute Lymphoblastic Leukemia (ALL); however, immune
responses and silent inactivation of the drug often limit its
bioavailability. Many strategies have been proposed to overcome these
drawbacks, including the development of improved formulations
(biobetters), but only two of them are currently on the market. Nano-
and micro-encapsulation are some of the most promising and novel
approaches to enhance in vivo performance of ASNase, preventing the
direct contact of the enzyme with the environment, protecting it from
protease degradation, increasing the enzymes catalytic half-life, and in
some cases, reducing immunogenicity. This review summarizes the
strategies, particularly for ASNase nano- and micro-encapsulation, and
their main findings, constraints, and current gaps in the
state-of-the-art knowledge. The pros and cons of the use of different
nanocarriers are discussed with the idea to ultimately provide safer and
more effective treatments for patients with ALL.
Filiaciones:
Villanueva-Flores, Francisca:
Centro de Nanociencias y Nanotecnología, Universidad Nacional Autónoma de México, Km. 107 Carretera Tijuana-Ensenada, Ensenada, 22860, Mexico
Zarate-Romero, Andres:
Centro de Nanociencias y Nanotecnología, Universidad Nacional Autónoma de México, Km. 107 Carretera Tijuana-Ensenada, Ensenada, 22860, Mexico
Torres, Alfredo G.:
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77550, United States
Huerta-Saquero, Alejandro:
Centro de Nanociencias y Nanotecnología, Universidad Nacional Autónoma de México, Km. 107 Carretera Tijuana-Ensenada, Ensenada, 22860, Mexico
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77550, United States
Green Published, gold, All Open Access; Gold
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