Cysticidal effect of a pure naphthoquinone on Taenia crassiceps cysticerci
Por:
Aranda-Lopez, Yuli, Lopez-Lopez, Lluvia, Nava Castro, Karen Elizabeth, Dolores Ponce-Regalado, Maria, Enrique Becerril-Villanueva, Luis, Ivan Giron-Perez, Manuel, Hugo Del Rio-Araiza, Victor, Morales-Montor, Jorge
Publicada:
1 nov 2021
Ahead of Print:
1 sep 2021
Resumen:
Cysticercosis is a disease caused by the metacestode of the parasite
Taenia solium (T. solium). In humans, the most severe complication of
the disease is neurocysticercosis. The drug of choice to treat this
disease is albendazole; however, the bioavailability and efficacy of the
drug are variable. Therefore, new molecules with therapeutic effects
against this and other parasitic infections caused by helminths must be
developed. Naphthoquinones are naphthalene-derived compounds that
possess antibacterial, antifungal, antitumoral, and antiparasitic
properties. The aim of this work was to evaluate the in vitro
anti-helminthic effect of
2-[(3-chlorophenylamino)phenylmethyl]-3-hydroxy-1,4-naphthoquinone,
isolated from a natural source and then synthesized (naphthoquinone 4a),
using an experimental model of murine cysticercosis caused by Taenia
crassiceps (T. crassiceps). This compound causes paralysis in the
cysticerci membrane from day 3 of the in vitro treatment. Additionally,
it induces changes in the shape, size, and appearance of the cysticerci
and a decrease in the reproduction rate. In conclusion, naphthoquinone
4a has in vitro cysticidal activity on T. crassiceps cysticerci
depending on the duration of the treatment and the concentration of the
compound. Therefore, it is a promising drug candidate to be used in T.
crassiceps and possibly T. solium infections.
Filiaciones:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Inmunol, Ciudad De Mexico 04510, Mexico
Univ Autonoma San Luis Potosi, Inst Invest Zonas Desert, San Luis Potosi, San Luis Potosi, Mexico
Univ Nacl Autonoma Mexico, Ctr Ciencias Atmosfera, Dept Ciencias Ambientales, Lab Genotoxicol & Med Ambientales, Ciudad De Mexico 04510, Mexico
Univ Guadalajara, Ctr Univ Los Altos, Dept Clin, Tepatitlan De Morelos, Jalisco, Mexico
Inst Nacl Psiquiatria Ramon de La Fuente, Dept Psicoinmunol, Ciudad De Mexico, Mexico
Univ Autonoma Nayarit, Lab Inmunotoxicol, Secretaria Invest & Posgrad, Cd Cultura S-N, Nayarit, Tepic, Mexico
Ctr Nayarita Innovac & Transferencia Tecnol, Unidad Especializada Lab Nacl Invest Inocuidad Al, LANIIA Unidad Nayarit, Calle Tres S-N, Nayarit, Tepic, Mexico
Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Dept Parasitol, Ciudad De Mexico 04510, Mexico
|