Aberrant Metabolism as Inductor of Epigenetic Changes in Breast Cancer: Therapeutic Opportunities
Por:
Coronel-Hernandez, Jossimar, Perez-Yepez, Eloy Andres, Delgado-Waldo, Izamary, Contreras-Romero, Carlos, Jacobo-Herrera, Nadia, Cantu-De Leon, David, Perez-Plasencia, Carlos
Publicada:
8 oct 2021
Resumen:
Aberrant metabolism is arising interest in the scientific community not
only because of the role it plays in the development and establishment
of the tumor mass but also the possibility of drug poisoning of key
enzymes overexpressed in tumor cells. Moreover, tumor metabolism
provides key molecules to maintain the epigenetic changes that are also
an undisputed characteristic of each tumor type. This metabolic change
includes the Warburg effect and alterations in key pathways involved in
glutaminolysis, pentose phosphate, and unsaturated fatty acid
biosynthesis. Modifications in all these pathways have consequences that
impact genetics and epigenetics processes such as DNA methylation
patterns, histone post-translational modifications, triggering oncogenes
activation, and loss in tumor suppressor gene expression to lead the
tumor establishment. In this review, we describe the metabolic
rearrangement and its association with epigenetic regulation in breast
cancer, as well as its implication in biological processes involved in
cancer progression. A better understanding of these processes could help
to find new targets for the diagnosis, prognosis, and treatment of this
human health problem.
Filiaciones:
Coronel-Hernandez, Jossimar:
Laboratorio de Genómica, Instituto Nacional de Cancerología, Mexico City, Mexico
Perez-Yepez, Eloy Andres:
Laboratorio de Genómica, Instituto Nacional de Cancerología, Mexico City, Mexico
Cátedra-CONACYT, Dirección de Cátedras, Consejo Nacional de Ciencia y Tecnología (CONACYT), Mexico City, Mexico
Delgado-Waldo, Izamary:
Laboratorio de Genómica, Instituto Nacional de Cancerología, Mexico City, Mexico
Contreras-Romero, Carlos:
Laboratorio de Genómica, Instituto Nacional de Cancerología, Mexico City, Mexico
Jacobo-Herrera, Nadia:
Unidad de Bioquímica, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico City, Mexico
Cantu-De Leon, David:
Unidad de Investigación en Cáncer, Instituto Nacional de Cancerología, Mexico City, Mexico
Perez-Plasencia, Carlos:
Laboratorio de Genómica, Instituto Nacional de Cancerología, Mexico City, Mexico
Laboratorio de Genómica Funcional, Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Mexico City, Mexico
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