Solid Lipid Nanoparticles: An Approach to Improve Oral Drug Delivery
Por:
Mendoza-Munoz, Nestor, Urban-Morlan, Zaida, Leyva-Gomez, Gerardo, de la Luz Zambrano-Zaragoza, Maria, Pinon-Segundo, Elizabeth, Quintanar-Guerrero, David
Publicada:
13 oct 2021
Resumen:
Nanoparticles have shown overall beneficial effects in drug
administration. Specifically, solid lipid nanoparticles (SLN) have
emerged as an alternative to polymer-based systems. However, the oral
administration of SLN, the first choice for conventional medications,
has not been addressed due to the taboo surrounding the complicated
transit that this delivery route entails. This review focuses on the
encapsulation of drugs into SLN as a strategy for improving oral
administration. Examples of applications of SLN to enhance the
absorption and bioavailability of poorly-soluble drugs and protect
acid-labile active molecules are discussed. This work also emphasizes
the importance of developing SLN-based systems to treat health issues
such as neurological diseases and cancer, and combat antibiotic
resistance, three significant and increasingly common current public
health problems. The review sections clarify how SLN can improve
bioavailability, target therapeutic agents, and reduce side effects.
Filiaciones:
Mendoza-Munoz, Nestor:
Univ Colima, Fac Ciencias Quim, Lab Farm, Colima, Mexico
Urban-Morlan, Zaida:
Univ Autonoma Yucatan, Fac Quim, Lab Cromatog, Merida, Yucatan, Mexico
Leyva-Gomez, Gerardo:
Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Ciudad De Mexico 04510, Mexico
de la Luz Zambrano-Zaragoza, Maria:
Univ Nacl Autonoma Mexico, Lab Proc Transformac & Tecnol Emergentes Alimento, FES Cuatitlan, Cuautitlan 54714, Mexico
Pinon-Segundo, Elizabeth:
Univ Nacl Autonoma Mexico, Fac Estudios Super Cuautitlan, Lab Sistemas Farmaceut Liberac Modificada, Unidad Invest Multidisciplinaria, L13, Edo De Mexico, Mexico
Quintanar-Guerrero, David:
Univ Nacl Autonoma Mexico, Fac Estudios Super Cuautitlan, Lab Posgrad Tecnol Farmaceut, Edo De Mexico, Mexico
gold, Gold
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