Effects of High Dietary Carbohydrate and Lipid Intake on the Lifespan of C. elegans
Por:
Franco-Juarez, Berenice, Gomez-Manzo, Saul, Hernandez-Ochoa, Beatriz, Cardenas-Rodriguez, Noemi, Arreguin-Espinosa, Roberto, de La Cruz V.P., Ortega-Cuellar, Daniel
Publicada:
1 sep 2021
Categoría:
Biochemistry, genetics and molecular biology (miscellaneous)
Resumen:
Health and lifespan are influenced by dietary nutrients, whose balance
is dependent on the supply or demand of each organism. Many studies have
shown that an increased carbohydrate-lipid intake plays a critical role
in metabolic dysregulation, which impacts longevity. Caenorhabditis
elegans has been successfully used as an in vivo model to study the
effects of several factors, such as genetic, environmental, diet, and
lifestyle factors, on the molecular mechanisms that have been linked to
healthspan, lifespan, and the aging process. There is evidence showing
the causative effects of high glucose on lifespan in different diabetic
models; however, the precise biological mechanisms affected by dietary
nutrients, specifically carbohydrates and lipids, as well as their links
with lifespan and longevity, remain unknown. Here, we provide an
overview of the deleterious effects caused by high-carbohydrate and
high-lipid diets, as well as the molecular signals that affect the
lifespan of C. elegans; thus, understanding the detailed molecular
mechanisms of high-glucose- and lipid-induced changes in whole organisms
would allow the targeting of key regulatory factors to ameliorate
metabolic disorders and age-related diseases.
Filiaciones:
Franco-Juarez, Berenice:
Departamento de Neurodesarrollo y Fisiología, División de Neurociencias, Instituto de Fisiología Celular, UNAM, Ciudad de México, 04510, Mexico
Ortega-Cuellar, D (Corresponding Author), Inst Nacl Pediat, Secretaria Salud, Lab Nutr Expt, Ciudad De Mexico 04530, Mexico. Franco-Juarez, Berenice, UNAM, Div Neurociencias, Inst Fisiol Celular, Dept Neurodesarrollo & Fisiol, Ciudad De Mexico 04510, Mexico. Gomez-Manzo, Saul, Inst Nacl Pediat, Secretaria Salud, Lab Bioquim Genet, Ciudad De Mexico 04530, Mexico. Hernandez-Ochoa, Beatriz, Hosp Infantil Mexico Dr Federico Gomez, Secretaria Salud, Lab Inmunoquim, Ciudad De Mexico 06720, Mexico. Car
Gomez-Manzo, Saul:
Laboratorio de Bioquímica Genética, Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de México, 04530, Mexico
Hernandez-Ochoa, Beatriz:
Laboratorio de Inmunoquímica, Hospital Infantil de México Federico Gómez, Secretaría de Salud, Ciudad de México, 06720, Mexico
Cardenas-Rodriguez, Noemi:
Laboratorio de Neurociencias, Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de México, 04530, Mexico
Arreguin-Espinosa, Roberto:
Departamento de Química de Biomacromoléculas, Instituto de Química, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico
de La Cruz V.P.:
Neurochemistry and Behavior Laboratory, National Institute of Neurology and Neurosurgery “Manuel Velasco Suárez”, Ciudad de México, 14269, Mexico
Ortega-Cuellar, Daniel:
Laboratorio de Nutrición Experimental, Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de México, 04530, Mexico
Green Published, gold, All Open Access, Gold, Green
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