Sensory and memory processing in old female and male Wistar rat brain, and its relationship with the cortical and hippocampal redox state
Por:
Santin-Marquez, Roberto, Ramirez-Cordero, Belen, Toledo-Perez, Rafael, Luna-Lopez, Armando, Lopez-Diazguerrero, Norma E., Hernandez-Arciga, Ulalume, Perez-Morales, Marcel, Ortíz-Retana J.J., Garcia-Servin, Martin, Alcauter, Sarael, Hernandez-Godinez, Braulio, Ibañez-Contreras A., Concha, Luis, Gomez-Gonzalez, Beatriz, Königsberg M.
Publicada:
1 ago 2021
Ahead of Print:
1 abr 2021
Resumen:
The brain is one of the most sensitive organs damaged during aging due
to its susceptibility to the aging-related oxidative stress. Hence, in
this study, the sensory nerve pathway integrity and the memory were
evaluated and related to the redox state, the antioxidant enzymes
function, and the protein oxidative damage in the brain cortex (Cx) and
the hippocampus (Hc) of young (4-month-old) and old (24-month-old) male
and female Wistar rats. Evoked potentials (EP) were performed for the
auditory, visual, and somatosensory pathways. In both males and females,
the old rat groups' latencies were larger in almost all waves when
compared to the young same-sex animals. The novel object test was
performed to evaluate memory. The superoxide dismutase and catalase
antioxidant activity, as well as the protein oxidative damage, and the
redox state were evaluated. Magnetic resonance (MR) imaging was used to
obtain the diffusion tensor imaging, and the brain volume, while MR
spectroscopy was used to obtain the brain metabolite concentrations
(glutamine, glutamate, Myo-inositol, N-acetyl-aspartate, creatine) in
the Cx and the Hc of young and old females. Our data suggest that,
although there are limited variations regarding memory and nerve
conduction velocity by sex, the differences concerning the redox status
might be important to explain the dissimilar reactions during brain
aging between males and females. Moreover, the increment in Myo-inositol
levels in the Hc of old rats and the brain volume decrease suggest that
redox state alterations might be correlated to neuroinflammation during
brain aging.
Filiaciones:
Santin-Marquez, Roberto:
Departamento de Ciencias de la Salud, DCBS, Universidad Autónoma Metropolitana Iztapalapa, México, CDMX 09340, Mexico
Posgrado en Biología Experimental, UAMI, México, Mexico
Ramirez-Cordero, Belen:
Departamento de Ciencias de la Salud, DCBS, Universidad Autónoma Metropolitana Iztapalapa, México, CDMX 09340, Mexico
Toledo-Perez, Rafael:
Departamento de Ciencias de la Salud, DCBS, Universidad Autónoma Metropolitana Iztapalapa, México, CDMX 09340, Mexico
Posgrado en Biología Experimental, UAMI, México, Mexico
Luna-Lopez, Armando:
Instituto Nacional de Geriatría, SSA, CDMX, 10200, Mexico
Lopez-Diazguerrero, Norma E.:
Departamento de Ciencias de la Salud, DCBS, Universidad Autónoma Metropolitana Iztapalapa, México, CDMX 09340, Mexico
Hernandez-Arciga, Ulalume:
Departamento de Ciencias de la Salud, DCBS, Universidad Autónoma Metropolitana Iztapalapa, México, CDMX 09340, Mexico
Perez-Morales, Marcel:
Departamento de Biología de la Reproducción, DCBS, Universidad Autónoma Metropolitana Iztapalapa, México, CDMX 09340, Mexico
Ortíz-Retana J.J.:
Laboratorio Nacional Enfocado en Imagenología por Resonancia Magnética, Instituto de Neurobiología, UNAM, Juriquilla, Mexico
Garcia-Servin, Martin:
Bioterio, Instituto de Neurobiología, UNAM, Juriquilla, Mexico
Alcauter, Sarael:
Laboratorio Nacional Enfocado en Imagenología por Resonancia Magnética, Instituto de Neurobiología, UNAM, Juriquilla, Mexico
Hernandez-Godinez, Braulio:
APREXBIO S.A.S de C.V., Laboratorio de Primatología, CDMX, Mexico
Ibañez-Contreras A.:
APREXBIO S.A.S de C.V., Laboratorio de Primatología, CDMX, Mexico
Concha, Luis:
Laboratorio Nacional Enfocado en Imagenología por Resonancia Magnética, Instituto de Neurobiología, UNAM, Juriquilla, Mexico
Gomez-Gonzalez, Beatriz:
Departamento de Biología de la Reproducción, DCBS, Universidad Autónoma Metropolitana Iztapalapa, México, CDMX 09340, Mexico
Königsberg M.:
Departamento de Ciencias de la Salud, DCBS, Universidad Autónoma Metropolitana Iztapalapa, México, CDMX 09340, Mexico
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