Cord blood levels of interleukin-10 decrease in neonates with increased birth weight: novel implications of the cytokine network in early obesity
Por:
Mendez-Garcia, Lucia Angelica, Minor-Borrego, Halili, Sanchez-Del Real, Ana Laura, Aguayo-Guerrero, Jose Alfredo, Alvarado-Monroy, Tania, Trejo-Millan, Fernanda, Rosas-Salinas, Jahaziel, Rizo-Tellez, Salma Alejandra, Islas-Andrade, Sergio, Briones-Garduno, Juan Carlos, Fragoso, Jose Manuel, Escobedo, Galileo
Publicada:
1 ago 2021
Ahead of Print:
1 may 2021
Categoría:
Pediatrics, perinatology and child health
Resumen:
Interleukin-10 (IL-10) and interferon-gamma (IFN-gamma) are associated
with body weight alterations in children, adolescents, and adults.
However, little is known regarding the role of IL-10 and IFN-gamma in
birth weight of neonates. One hundred eighty-two infants were enrolled
and divided in groups of normal birth weight (< 95th percentile) or
increased birth weight (> 95th percentile) for gestational age. IL-10
and IFN-gamma levels were measured in umbilical cord tissue and blood of
newborns by quantitative polymerase chain reaction (qPCR) and
enzyme-linked immunosorbent assay (ELISA). The average value of birth
weight in infants below and above the 95th percentile was 3.03 +/- 0.39
and 3.58 +/- 0.37 kg, respectively, and was independent of the mother's
pre-gestational body mass index. The Student t test revealed that
neonates with birth weights > 95th percentile show a significant 30%
decrease in cord blood values of IL-10 as compared to infants with birth
weights < 95th percentile (P<0.0001), with no significant changes in
IFN-gamma levels (P=0.1661). Cord blood IL-10 was not of maternal origin
but produced by umbilical cord tissue that showed less IL-10 expression
in neonates with birth weights > 95th percentile than in infants with
birth weights < 95th percentile (P=0.0252). Cord blood levels of IL-10
exhibited significant inverse correlations with birth weight (r = -
0.658, P=0.002) and INF-gamma (r = - 0.502, P=0.005). Conclusion: In
conclusion, this work demonstrates for the first time that cord blood
IL-10 decreases as birth weight increases in infants born at term and
might help to improve early recognition of newborns at higher risk of
developing obesity in childhood or adulthood.
What is Known: center dot Reduction in interleukin-10 levels has been
associated with obesity in adolescents and adults but not newborns.
center dot The number of neonates with excess birth weight has
alarmingly increased in the last 30 years. What is New: center dot We
demonstrate that umbilical cord blood levels of interleukin-10 clearly
decrease as birth weight increases. center dot Interleukin-10 and
interferon-gamma integrate a cytokine network that might play a role in
obesity in infants.
Filiaciones:
Mendez-Garcia, Lucia Angelica:
Escobedo, G (Corresponding Author), Gen Hosp Mexico Dr Eduardo Liceaga, Div Res, Lab Immunometab, Mexico City 06720, DF, Mexico. Mendez-Garcia, Lucia Angelica
Minor-Borrego, Halili:
Escobedo, G (Corresponding Author), Gen Hosp Mexico Dr Eduardo Liceaga, Div Res, Lab Immunometab, Mexico City 06720, DF, Mexico. Mendez-Garcia, Lucia Angelica
Sanchez-Del Real, Ana Laura:
Escobedo, G (Corresponding Author), Gen Hosp Mexico Dr Eduardo Liceaga, Div Res, Lab Immunometab, Mexico City 06720, DF, Mexico. Mendez-Garcia, Lucia Angelica
Aguayo-Guerrero, Jose Alfredo:
Escobedo, G (Corresponding Author), Gen Hosp Mexico Dr Eduardo Liceaga, Div Res, Lab Immunometab, Mexico City 06720, DF, Mexico. Mendez-Garcia, Lucia Angelica
Alvarado-Monroy, Tania:
Escobedo, G (Corresponding Author), Gen Hosp Mexico Dr Eduardo Liceaga, Div Res, Lab Immunometab, Mexico City 06720, DF, Mexico. Mendez-Garcia, Lucia Angelica
Trejo-Millan, Fernanda:
Escobedo, G (Corresponding Author), Gen Hosp Mexico Dr Eduardo Liceaga, Div Res, Lab Immunometab, Mexico City 06720, DF, Mexico. Mendez-Garcia, Lucia Angelica
Rosas-Salinas, Jahaziel:
Escobedo, G (Corresponding Author), Gen Hosp Mexico Dr Eduardo Liceaga, Div Res, Lab Immunometab, Mexico City 06720, DF, Mexico. Mendez-Garcia, Lucia Angelica
Rizo-Tellez, Salma Alejandra:
Escobedo, G (Corresponding Author), Gen Hosp Mexico Dr Eduardo Liceaga, Div Res, Lab Immunometab, Mexico City 06720, DF, Mexico. Mendez-Garcia, Lucia Angelica
Islas-Andrade, Sergio:
Escobedo, G (Corresponding Author), Gen Hosp Mexico Dr Eduardo Liceaga, Div Res, Lab Immunometab, Mexico City 06720, DF, Mexico. Mendez-Garcia, Lucia Angelica
Briones-Garduno, Juan Carlos:
Escobedo, G (Corresponding Author), Gen Hosp Mexico Dr Eduardo Liceaga, Div Res, Lab Immunometab, Mexico City 06720, DF, Mexico. Mendez-Garcia, Lucia Angelica
Fragoso, Jose Manuel:
Escobedo, G (Corresponding Author), Gen Hosp Mexico Dr Eduardo Liceaga, Div Res, Lab Immunometab, Mexico City 06720, DF, Mexico. Mendez-Garcia, Lucia Angelica
Escobedo, Galileo:
Escobedo, G (Corresponding Author), Gen Hosp Mexico Dr Eduardo Liceaga, Div Res, Lab Immunometab, Mexico City 06720, DF, Mexico. Mendez-Garcia, Lucia Angelica
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