Risk factors associated with the development of interstitial lung abnormalities
Por:
Buendia-Roldan, Ivette, Fernandez, Rosario, Mejia, Mayra, Juarez, Fortunato, Ramirez-Martinez, Gustavo, Montes, Eduardo, Pruneda, Ana Karem S., Martinez-Espinosa, Karen, Alarcon-Dionet, Aime, Herrera, Iliana, Becerril, Carina, Chavez-Galan, Leslie, Preciado, Mario, PARDO, ANNIE, Selman, Moises
Publicada:
1 ago 2021
Resumen:
Background Around 8-10% of individuals over 50 years of age present
interstitial lung abnormalities (ILAs), but their risk factors are
uncertain.
Methods From 817 individuals recruited in our lung ageing programme at
the Mexican National Institute of Respiratory Diseases, 80 (9.7%)
showed ILAs and were compared with 564 individuals of the same cohort
with normal high-resolution computed tomography to evaluate demographic
and functional differences, and with 80 individuals randomly selected
from the same cohort for biomarkers. We evaluated MUC5B variant
rs35705950, telomere length, and serum levels of matrix
metalloproteinase (MMP)-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12,
MMP-13, interleukin (IL)-6, surfactant protein (SP)-D, alpha-Klotho and
resistin.
Results Individuals with ILAs were usually males (p<0.005), older than
controls (p<0.0001), smokers (p=0.01), with a greater frequency of MUC5B
rs35705950 (OR 3.5, 95% CI 1.3-9.4; p=0.01), and reduced diffusing
capacity of the lung for carbon monoxide and oxygen saturation.
Resistin, IL-6, SP-D, MMP-1, MMP-7 and MMP-13 were significantly
increased in individuals with ILAs. Resistin (12 +/- 5 versus 9 +/- 4
ngmiddotmL-1; p=0.0005) and MMP-13 (357 +/- 143 versus 298 +/- 116
pgmiddotmL-1; p=0.004) were the most increased biomarkers. On follow-up
(24 +/- 18 months), 18 individuals showed progression which was
associated with gastro-oesophageal reflux disease (OR 4.1, 95% CI
1.2-12.9; p=0.02) and in females with diabetes mellitus (OR 5.3, 95% CI
1.0-27.4; p=0.01).
Conclusions Around 10% of respiratory asymptomatic individuals enrolled
in our lung ageing programme show ILAs. Increased serum concentrations
of pro-inflammatory molecules and MMPs are associated with ILAs.
Filiaciones:
Selman, M (Corresponding Author), Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Mexico City, DF, Mexico. Buendia-Roldan, Ivette
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