High Levels of IL-8 and MCP-1 in Cerebrospinal Fluid of COVID-19 Patients with Cerebrovascular Disease
Por:
Guartazaca-Guerrero, Sebastian, Rodriguez-Morales, Jahir, Rizo-Tellez, Salma A., Solleiro-Villavicencio, Helena, Hernandez-Valencia, Aldo F., Damian Carrillo-Ruiz, Jose, Escobedo, Galileo, Mendez-Garcia, Lucia A.
Publicada:
1 jun 2021
Resumen:
The coronavirus family has tropism for the Central Nervous System (CNS),
however, there is no solid evidence demonstrating that the neurological
effects of COVID-19 result from direct viral infection or systemic
inflammation. The goals of this study were to examine the cytokine
profile and the presence of SARS-CoV-2 messenger ribonucleic acid (mRNA)
in cerebrospinal fluids (CSF) from two patients with cerebrovascular
disease and COVID-19. Although the SARS-CoV-2 mRNA was not detected in
CSF of both patients, we found abnormally high levels of numerous
proinflammatory cytokines and chemokines, especially IL-8 and MCP-1.
Since these chemokines mediate activation and recruitment of
neutrophils, monocytes, and macrophages, it is feasible that
cerebrovascular disease related-neuroinflammation found in both patients
results from an exacerbated inflammatory response instead of SARS-CoV-2
direct invasion to CNS. These results suggest that neuroinflammation
plays a key role in cerebrovascular disease and COVID-19.
Filiaciones:
Guartazaca-Guerrero, Sebastian:
Univ Nacl Autonoma Mexico, Fac Med, Neurocirugia, Mexico City 04510, DF, Mexico
Gen Hosp Mexico Dr Eduardo Liceaga, Neurol & Neurosurg Unit, Mexico City 06720, DF, Mexico
Rodriguez-Morales, Jahir:
Univ Nacl Autonoma Mexico, Fac Med, Neurocirugia, Mexico City 04510, DF, Mexico
Gen Hosp Mexico Dr Eduardo Liceaga, Neurol & Neurosurg Unit, Mexico City 06720, DF, Mexico
Rizo-Tellez, Salma A.:
Gen Hosp Mexico Dr Eduardo Liceaga, Res Div, Lab Immunometab, Mexico City 06720, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Med, PECEM, Mexico City 04510, DF, Mexico
Solleiro-Villavicencio, Helena:
Univ Autonoma Ciudad Mexico, Posgrad Ciencias Genom, Mexico City 03100, DF, Mexico
Hernandez-Valencia, Aldo F.:
Gen Hosp Mexico Dr Eduardo Liceaga, Neurol & Neurosurg Unit, Mexico City 06720, DF, Mexico
Damian Carrillo-Ruiz, Jose:
Gen Hosp Mexico Dr Eduardo Liceaga, Neurol & Neurosurg Unit, Mexico City 06720, DF, Mexico
Univ Anahuac, Fac Ciencias Salud, Campus Norte, Huixquilucan 52786, Estado De Mexic, Mexico
Escobedo, Galileo:
Gen Hosp Mexico Dr Eduardo Liceaga, Res Div, Lab Immunometab, Mexico City 06720, DF, Mexico
Mendez-Garcia, Lucia A.:
Gen Hosp Mexico Dr Eduardo Liceaga, Res Div, Lab Immunometab, Mexico City 06720, DF, Mexico
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