Evaluating of Red Blood Cell Distribution Width, Comorbidities and Electrocardiographic Ratios as Predictors of Prognosis in Patients with Pulmonary Hypertension
Por:
Baltazares-Lipp, Mario E., Aguilera-Velasco, Alberto, Aquino-Galvez, Arnoldo, Velazquez-Cruz, Rafael, Hernandez-Zenteno, Rafael J., Alvarado-Vasquez, Noe, Camarena, Angel, Patricia Sierra-Vargas, M., Chavez-Pacheco, Juan L., Ruiz, Victor, Salinas-Lara, Citlaltepetl, Tena-Suck, Martha L., Romero, Yair, Torres-Espindola, Luz M., Castillejos-Lopez, Manuel
Publicada:
1 jul 2021
Categoría:
Clinical biochemistry
Resumen:
Pulmonary hypertension is a rare condition that impairs patients'
quality of life and life expectancy. The development of noninvasive
instruments may help elucidate the prognosis of this cardiorespiratory
disease. We aimed to evaluate the utility of routinely performed
noninvasive test results as prognostic markers in patients with
pulmonary hypertension. We enrolled 198 patients with mean pulmonary
artery pressure >25 mmHg measured at cardiac catheterisation or
echocardiographic pulmonary artery systolic pressure > 40 mmHg and
tricuspid regurgitation Vmax >2.9 m/s, and clinical information
regarding management and follow-up studies from the date of diagnosis.
Multivariate analysis revealed that female sex [HR: 0.21, (95% CI:
0.07-0.64); p = 0.006], the presence of collagenopathies [HR: 8.63,
(95% CI: 2.38-31.32); p = 0.001], an increased red blood cell
distribution width [HR: 1.25, (95% CI: 1.04-1.49); p = 0.017] and an
increased electrocardiographic P axis (P degrees)/T axis (T degrees)
ratio [HR: 0.93, (95% CI: 0.88-0.98); p = 0.009] were
severity-associated factors, while older age [HR: 1.57, (95% CI:
1.04-1.28); p = 0.006], an increased QRS axis (QRS degrees)/T degrees
ratio [HR: 1.21, (95% CI: 1.09-1.34); p < 0.001], forced expiratory
volume in 1 s [HR: 0.94, (95% CI: 0.91-0.98); p = 0.01] and
haematocrit [HR: 0.93, (95% CI: 0.87-0.99); p = 0.04] were
mortality-associated factors. Our results support the importance of red
blood cell distribution width, electrocardiographic ratios and
collagenopathies for assessing pulmonary hypertension prognosis.
Filiaciones:
Natl Inst Resp Dis Ismael Cosio Villegas, Dept Hemodynam & Echocardiog, Mexico City 14080, DF, Mexico
Natl Inst Resp Dis Ismael Cosio Villegas, Epidemiol & Stat Dept, Mexico City 14080, DF, Mexico
Natl Inst Resp Dis Ismael Cosio Villegas, Pulm Fibrosis Res Dept, Lab Mol Biol, Mexico City 14080, DF, Mexico
Natl Inst Genom Med INMEGEN, Genom Bone Metab Lab, Mexico City 14610, DF, Mexico
Natl Inst Resp Dis Ismael Cosio Villegas, Clin Serv Chron Obstruct Pulm Dis, Mexico City 14080, DF, Mexico
Natl Inst Resp Dis Ismael Cosio Villegas, Biochem Dept, Mexico City 14080, DF, Mexico
Natl Inst Resp Dis Ismael Cosio Villegas, Lab HLA, Mexico City 14080, DF, Mexico
Natl Inst Resp Dis Ismael Cosio Villegas, Toxicol & Environm Med Res Dept, Mexico City 14080, DF, Mexico
Natl Inst Paediat, Lab Pharmacol, Mexico City 04530, DF, Mexico
Natl Inst Neurol & Neurosurg, Lab Neuropathol, Mexico City 14269, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Sci, Mexico City 04510, DF, Mexico
Green Published, gold, All Open Access, Gold, Green
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