Expression of Surfactant Protein D Distinguishes Severe Pandemic Influenza A(H1N1) from Coronavirus Disease 2019
Por:
Alberto Choreno-Parra, Jose, Armando Jimenez-Alvarez, Luis, Ramirez-Martinez, Gustavo, Cruz-Lagunas, Alfredo, Thapa, Mahima, Alejandro Fernandez-Lopez, Luis, Carnalla-Cortes, Martha, Choreno-Parra, Eduardo M., Mena-Hernandez, Lourdes, Sandoval-Vega, Montserrat, Mariana Hernandez-Montiel, Erika, Lizzeth Hernandez-Garcia, Diana, Ariadna Ramirez-Noyola, Jazmin, Estefania Reyes-Lopez, Cynthia, Dominguez-Faure, Andrea, Yamil Zamudio-Lopez, Guillermo, Marquez-Garcia, Eduardo, Moncada-Morales, Angelica, Mendoza-Milla, Criselda, Cervantes-Rosete, Diana, Munoz-Torrico, Marcela, Luna-Rivero, Cesar, Garcia-Latorre, Ethel A., Guadarrama-Ortiz, Parmenides, Avila-Moreno, Federico, Dominguez-Cherit, Guillermo, Sofia Rodriguez-Reyna, Tatiana, Mudd, Philip A., Margarita Hernandez-Cardenas, Carmen, Khader, Shabaana A., Zuniga, Joaquin
Publicada:
1 jul 2021
Resumen:
The differentiation between influenza and coronavirus disease 2019
(COVID-19) could constitute a diagnostic challenge during the ongoing
winter owing to their clinical similitude. Thus, novel biomarkers are
required to enable making this distinction. Here, we evaluated whether
the surfactant protein D (SP-D), a collectin produced at the alveolar
epithelium with known immune properties, was useful to differentiate
pandemic influenza A(H1N1) from COVID-19 in critically ill patients. Our
results revealed high serum SP-D levels in patients with severe pandemic
influenza but not those with COVID-19. This finding was validated in a
separate cohort of mechanically ventilated patients with COVID-19 who
also showed low plasma SP-D levels. However, plasma SP-D levels did not
distinguish seasonal influenza from COVID-19 in mild-to-moderate
disease. Finally, we found that high serum SP-D levels were associated
with death and renal failure among severe pandemic influenza cases.
Thus, our studies have identified SP-D as a unique biomarker expressed
during severe pandemic influenza but not COVID-19.
Filiaciones:
Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Mexico City, DF, Mexico
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Lab Inmunobiol & Genet, Mexico City, DF, Mexico
Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA
Inst Nacl Salud Publ, Ctr Invest Salud Poblac, Cuernavaca, Morelos, Mexico
Univ Nacl Autonoma Mexico, Posgrad Ciencias Biol, Mexico City, DF, Mexico
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Dermatol, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Tlalnepantla De Baz, Mexico
Tecnol Monterrey, Escuela Med & Ciencias Salud, Mexico City, DF, Mexico
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Resp Crit Care Unit, Mexico City, DF, Mexico
Inst Nacl Enfermedades Resp Isamel Cosio Villegas, Dept Fibrosis Pulm, Mexico City, DF, Mexico
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Immunol & Reumathol, Mexico City, DF, Mexico
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Clin TB, Mexico City, DF, Mexico
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Dept Pathol, Mexico City, DF, Mexico
Ctr Especializado Neurocirugia & Neurociencias Me, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Biomed Res Unit, Lung Dis & Canc Epigen Lab, Tlalnepantla De Baz, Mexico
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Intens Care Unit, Mexico City, DF, Mexico
Washington Univ, Dept Emergency Med, Sch Med St Louis, St Louis, MO USA
Washington Univ, Sch Med St Louis, Dept Mol Microbiol, St Louis, MO USA
Bronze, Green Published
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