The role of extracellular DNA (exDNA) in cellular processes
Por:
Fernandez-Dominguez, Ileana J., Manzo-Merino, Joaquin, Taja-Chayeb, Lucia, Duenas-Gonzalez, Alfonso, Perez-Cardenas, Enrique, Trejo-Becerril, Catalina
Publicada:
3 abr 2021
Ahead of Print:
1 mar 2021
Resumen:
Nowadays, extracellular DNA or circulating cell-free DNA is considered
to be a molecule with clinical applications (diagnosis, prognosis,
monitoring of treatment responses, or patient follow-up) in diverse
pathologies, especially in cancer. Nevertheless, because of its
molecular characteristics, it can have many other functions. This review
focuses on the participation of extracellular DNA (exDNA) in fundamental
processes such as cell signaling, coagulation, immunity, evolution
through horizontal transfer of genetic information, and adaptive
response to inflammatory processes. A deeper understanding of its role
in each of these processes will allow development of better tools to
monitor and control pathologies, as well as helping to generate new
therapeutic options, beyond the applicability of DNA in liquid biopsy.
Filiaciones:
Fernandez-Dominguez, Ileana J.:
Inst Nacl Cancerol, Div Basic Res, Mexico City, DF, Mexico
Manzo-Merino, Joaquin:
Inst Nacl Cancerol, Div Basic Res, Mexico City, DF, Mexico
Taja-Chayeb, Lucia:
Inst Nacl Cancerol, Div Basic Res, Mexico City, DF, Mexico
Duenas-Gonzalez, Alfonso:
Inst Nacl Cancerol, Div Basic Res, Mexico City, DF, Mexico
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City, DF, Mexico
Perez-Cardenas, Enrique:
Inst Nacl Cancerol, Div Basic Res, Mexico City, DF, Mexico
Trejo-Becerril, Catalina:
Inst Nacl Cancerol, Div Basic Res, Mexico City, DF, Mexico
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