Bioactive Synthetic Peptides for Oral Tissues Regeneration
Por:
Bermudez, Mercedes, Hoz, Lia, Montoya, Gonzalo, Nidome, Mikado, Perez-Soria, Adriana, Romo, Enrique, Soto-Barreras, Uriel, Garnica-Palazuelos, Julio, Aguilar-Medina, Maribel, Ramos-Payan, Rosalio, Villegas-Mercado, Carlos
Publicada:
23 abr 2021
Categoría:
Materials science (miscellaneous)
Resumen:
Regenerative therapy in oral tissues has gained relevance since tissue
loss due to congenital or acquired diseases as well as trauma is a major
health problem worldwide. Regeneration depends on the natural capacity
of the body and the use of biomaterials and bioactive molecules that can
module the processes to replace lost or damaged tissues and restore
function. The combined use of scaffolds, cells, and bioactive molecules
such as peptides is considered the best approach to achieve tissue
regeneration. These peptides can induce diverse cellular processes as
they can influence cell behavior and also can modify scaffold
properties, giving as a result the enhancement of cell adhesion,
proliferation, migration, differentiation, and biomineralization that
are required given the complex nature of oral tissues. Specifically,
synthetic peptides (SP) have a positive influence on scaffold
biocompatibility since in many cases they can mimic the function of a
natural peptide or a full-length protein. Besides, they are bioactive
molecules easy to produce, process, and modify, and they can be prepared
under well-defined and controlled conditions. This review aims to
compile the most relevant information regarding advances in SP for
dental and periodontal tissue regeneration, their biological effects,
and their clinical implications. Even though most of the SP are still
under investigation, some of them have been studied in vitro and in vivo
with promising results that may lead to preclinical studies. Besides
there are SP that have shown their efficacy in clinical trials such as
P11-4 for enamel regeneration or caries prevention and ABM/P-15 for
cementum, periodontal ligament (PDL), and alveolar bone on a previously
calculus- and biofilm-contaminated zone. Also, some SP are commercially
available such as PTH1-34 and PepGen P-15 which are used for bone
defects treatment.
Filiaciones:
Bermudez, Mercedes:
Univ Autonoma Sinaloa, Fac Ciencias Quim Biol, Culiacan, Sinaloa, Mexico
Hoz, Lia:
Univ Nacl Autonoma Mexico, Fac Odontol, Mexico City, DF, Mexico
Montoya, Gonzalo:
Univ Nacl Autonoma Mexico, Fac Odontol, Mexico City, DF, Mexico
Nidome, Mikado:
Univ Nacl Autonoma Mexico, Fac Odontol, Mexico City, DF, Mexico
Perez-Soria, Adriana:
Univ Nacl Autonoma Mexico, Fac Odontol, Mexico City, DF, Mexico
Romo, Enrique:
Univ Nacl Autonoma Mexico, Fac Odontol, Mexico City, DF, Mexico
Soto-Barreras, Uriel:
Univ Autonoma Chihuahua, Fac Odontol, Chihuahua, Chihuahua, Mexico
Garnica-Palazuelos, Julio:
Univ Autonoma Sinaloa, Fac Odontol, Culiacan, Sinaloa, Mexico
Aguilar-Medina, Maribel:
Univ Autonoma Sinaloa, Fac Ciencias Quim Biol, Culiacan, Sinaloa, Mexico
Ramos-Payan, Rosalio:
Univ Autonoma Sinaloa, Fac Ciencias Quim Biol, Culiacan, Sinaloa, Mexico
Villegas-Mercado, Carlos:
Univ Autonoma Sinaloa, Fac Odontol, Culiacan, Sinaloa, Mexico
Gold, All Open Access; Gold
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