Regulatory T Cells as an Escape Mechanism to the Immune Response in Taenia crassiceps Infection
Por:
Adalid-Peralta, Laura, Lopez-Roblero, Alexander, Camacho-Vazquez, Cynthia, Najera-Ocampo, Marisol, Guevara-Salinas, Adrian, Ruiz-Monroy, Nataly, Melo-Salas, Marlene, Morales-Ruiz, Valeria, Lopez-Recinos, Dina, Ortiz-Hernandez, Edgar, Demengeot, Jocelyne, Vazquez-Perez, Joel A., Arce-Sillas, Asiel, Gomez-Fuentes, Sandra, Parkhouse, Robert Michael Evans, Fragoso, Gladis, Sciutto, Edda, Sevilla-Reyes, Edgar E.
Publicada:
13 abr 2021
Resumen:
Murine cysticercosis by Taenia crassiceps is a model for human
neurocysticercosis. Genetic and/or immune differences may underlie the
higher susceptibility to infection in BALB/cAnN with respect to C57BL/6
mice. T regulatory cells (Tregs) could mediate the escape of T.
crassiceps from the host immunity. This study is aimed to investigate
the role of Tregs in T. crassiceps establishment in susceptible and
non-susceptible mouse strains. Treg and effector cells were quantified
in lymphoid organs before infection and 5, 30, 90, and 130 days
post-infection. The proliferative response post-infection was
characterized in vitro. The expression of regulatory and inflammatory
molecules was assessed on days 5 and 30 post-infection. Depletion assays
were performed to assess Treg functionality. Significantly higher Treg
percentages were observed in BALB/cAnN mice, while increased percentages
of activated CD127+ cells were found in C57BL/6 mice. The proliferative
response was suppressed in susceptible mice, and Treg proliferation
occurred only in susceptible mice. Treg-mediated suppression mechanisms
may include IL-10 and TGF beta secretion, granzyme- and
perforin-mediated cytolysis, metabolic disruption, and cell-to-cell
contact. Tregs are functional in BALB/cAnN mice. Therefore Tregs could
be allowing parasite establishment and survival in susceptible mice but
could play a homeostatic role in non-susceptible strains.
Filiaciones:
Adalid-Peralta, Laura:
Univ Nacl Autonoma Mexico, Inst Nacl Neurol & Neurocirugia Mexico, Inst Invest Biomed, Unidad Perifer Estudio Neuroinflamac Patol Neurol, Mexico City, DF, Mexico
Inst Nacl Neurol & Neurocirug, Mexico City, DF, Mexico
Lopez-Roblero, Alexander:
Univ Autonoma Chiapas, Fac Ciencias Quim, Tapachula, Mexico
Camacho-Vazquez, Cynthia:
Univ Nacl Autonoma Mexico, Inst Nacl Neurol & Neurocirugia Mexico, Inst Invest Biomed, Unidad Perifer Estudio Neuroinflamac Patol Neurol, Mexico City, DF, Mexico
Najera-Ocampo, Marisol:
Univ Nacl Autonoma Mexico, Inst Nacl Neurol & Neurocirugia Mexico, Inst Invest Biomed, Unidad Perifer Estudio Neuroinflamac Patol Neurol, Mexico City, DF, Mexico
Guevara-Salinas, Adrian:
Univ Nacl Autonoma Mexico, Inst Nacl Neurol & Neurocirugia Mexico, Inst Invest Biomed, Unidad Perifer Estudio Neuroinflamac Patol Neurol, Mexico City, DF, Mexico
Ruiz-Monroy, Nataly:
Univ Nacl Autonoma Mexico, Inst Nacl Neurol & Neurocirugia Mexico, Inst Invest Biomed, Unidad Perifer Estudio Neuroinflamac Patol Neurol, Mexico City, DF, Mexico
Melo-Salas, Marlene:
Univ Nacl Autonoma Mexico, Inst Nacl Neurol & Neurocirugia Mexico, Inst Invest Biomed, Unidad Perifer Estudio Neuroinflamac Patol Neurol, Mexico City, DF, Mexico
Morales-Ruiz, Valeria:
Univ Nacl Autonoma Mexico, Inst Nacl Neurol & Neurocirugia Mexico, Inst Invest Biomed, Unidad Perifer Estudio Neuroinflamac Patol Neurol, Mexico City, DF, Mexico
Lopez-Recinos, Dina:
Univ Nacl Autonoma Mexico, Inst Nacl Neurol & Neurocirugia Mexico, Inst Invest Biomed, Unidad Perifer Estudio Neuroinflamac Patol Neurol, Mexico City, DF, Mexico
Ortiz-Hernandez, Edgar:
Univ Nacl Autonoma Mexico, Inst Nacl Neurol & Neurocirugia Mexico, Inst Invest Biomed, Unidad Perifer Estudio Neuroinflamac Patol Neurol, Mexico City, DF, Mexico
Demengeot, Jocelyne:
Inst Gulbenkian Ciencias, Oeiras, Portugal
Vazquez-Perez, Joel A.:
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Dept Invest Enfermedades Infecciosas, Tlalpan, Mexico
Arce-Sillas, Asiel:
Univ Nacl Autonoma Mexico, Inst Nacl Neurol & Neurocirugia Mexico, Inst Invest Biomed, Unidad Perifer Estudio Neuroinflamac Patol Neurol, Mexico City, DF, Mexico
Gomez-Fuentes, Sandra:
Univ Nacl Autonoma Mexico, Inst Nacl Neurol & Neurocirugia Mexico, Inst Invest Biomed, Unidad Perifer Estudio Neuroinflamac Patol Neurol, Mexico City, DF, Mexico
Parkhouse, Robert Michael Evans:
Inst Gulbenkian Ciencias, Oeiras, Portugal
Fragoso, Gladis:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Inmunol, Mexico City, DF, Mexico
Sciutto, Edda:
Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Inmunol, Mexico City, DF, Mexico
Sevilla-Reyes, Edgar E.:
Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Dept Invest Enfermedades Infecciosas, Tlalpan, Mexico
Gold, Green Published, All Open Access; Gold
|