Class I HDAC inhibition improves object recognition memory consolidation through BDNF/TrkB pathway in a time-dependent manner
Por:
Ramirez-Mejia, Gerardo, Gil-Lievana, Elvi, Urrego-Morales, Oscar, Soto-Reyes, Ernesto, Bermudez-Rattoni, Federico
Publicada:
1 abr 2021
Resumen:
There is increasing evidence showing that HDACs regulates BDNF
(brain-derived neurotrophic factor) expression through its interaction
with the Bdnf gene promoter, a key regulator to consolidate memory.
Although the nuclear mechanisms regulated by HDACs that control BDNF
expression have been partially described recently, the temporal events
for memory consolidation remain unknown. Hence, in this work, we studied
the temporal pattern for the activation of the BDNF/TrkB pathway through
class I HDAC inhibition to enhance object recognition memory (ORM)
consolidation. To this end, we inhibited class I HDAC into the insular
cortex (IC) and a weak ORM protocol was used to assess temporal
expression and function of the BDNF/TrkB pathway in the IC. We found
that cortical class I HDAC inhibition enhanced long-term ORM, coincident
with a clear peak of BDNF expression at 4 h after acquisition.
Furthermore, the tyrosine kinase B (TrkB) receptor blockade at 4 h, but
not at 8 h, impaired the consolidation of ORM. These results suggest
that histone acetylation regulates the temporal expression of BDNF in
cortical circuits potentiating the long-term recognition memory.
Filiaciones:
Ramirez-Mejia, Gerardo:
División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México04510, Mexico
Gil-Lievana, Elvi:
División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México04510, Mexico
Urrego-Morales, Oscar:
División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México04510, Mexico
Soto-Reyes, Ernesto:
Departamento de Ciencias Naturales, Universidad Autónoma Metropolitana, Unidad Cuajimalpa, 05348, Mexico
Bermudez-Rattoni, Federico:
División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México04510, Mexico
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