A meta-study on transcription factor networks in the suicidal brain
Por:
Cabrera-Mendoza, Brenda, de Anda-Jauregui, Guillermo, Nicolini, Humberto, Fresno, Cristobal
Publicada:
1 abr 2021
Resumen:
There is evidence supporting the presence of brain gene expression
differences between suicides and nonsuicides. Such differences have been
implicated in suicide pathophysiology. However, regulatory factors
underlying these gene expression differences have not been fully
understood. Therefore, the identification of differences in regulatory
mechanisms, i.e., transcriptional factors between suicides and
non-suicides is crucial for the understanding of suicide neurobiology.
In this study, we conducted a transcription factor network meta-study
with freely available data from the prefrontal cortex of suicides and
non-suicides with different mental disorders, including major depression
disorder, bipolar disorder and schizophrenia, as well as healthy
controls. Disorderspecific characteristics of suicides and non-suicides
transcription factor networks were detected, i.e., the presence of
immune response genes in both suicides and non-suicides with major
depression disorder networks. Also, we found the presence of ESR1, which
has been implicated to give resilience to social stress, in the
non-suicides network but not in the suicides with major depression
network. Suicides and non-suicides with bipolar disorder shared only
three genes in common: FOS, CRY1 and PER2. In addition, we found a
higher number of genes involved in immune response in the non-suicides
with bipolar disorder compared to the suicides with bipolar disorder
network. The suicides and non-suicides with schizophrenia networks
exhibited clear differences, including the presence of circadian cycle
genes in the suicides with schizophrenia network and their absence in
the non-suicides with schizophrenia network. The results of this study
provide insight on the regulatory mechanisms underpinning
transcriptional changes in the suicidal brain.
Filiaciones:
Laboratorio de Genómica de Enfermedades Psiquiátricas, Neurodegenerativas y Adicciones, National Institute of Genomic Medicine (INMEGEN), Mexico City, 14610, Mexico
Plan of Combined Studies in Medicine (PECEM), Facultad de Medicina, National Autonomous University of Mexico, Mexico City, 04510, Mexico
Departamento de Genómica Computacional, National Institute of Genomic Medicine (INMEGEN), Mexico City, 14610, Mexico
Programa de Cátedras CONACYT para Jóvenes Investigadores, Mexico City, 03940, Mexico
Departamento de Desarrollo Tecnológico, National Institute of Genomic Medicine (INMEGEN), Mexico City, 14610, Mexico
Natl Inst Genom Med INMEGEN, Lab Genom Enfermedades Psiquiatr Neurodegenerat &, Mexico City 14610, DF, Mexico
Univ Nacl Autonoma Mexico, Fac Med, Plan Combined Studies Med PECEM, Mexico City 04510, DF, Mexico
Natl Inst Genom Med INMEGEN, Dept Genom Computac, Mexico City 14610, DF, Mexico
Programa Catedras CONACYT Jovenes Invest, Mexico City 03940, DF, Mexico
Natl Inst Genom Med INMEGEN, Dept Desarrollo Tecnol, Perifer Sur 4809, Mexico City 14610, DF, Mexico
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