Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence
Por:
Salehi, Bahare, Quispe, Cristina, Chamkhi, Imane, El Omari, Nasreddine, Balahbib, Abdelaali, Sharifi-Rad, Javad, Bouyahya, Abdelhakim, Akram, Muhammad, Iqbal, Mehwish, Docea, Anca Oana, Caruntu, Constantin, Leyva-Gomez, Gerardo, Dey, Abhijit, Martorell, Miquel, Calina, Daniela, Lopez, Victor, Les, Francisco
Publicada:
1 ene 2021
Resumen:
Chalcones are among the leading bioactive flavonoids with a therapeutic potential implicated to an array of bioactivities investigated by a series of preclinical and clinical studies. In this article, different scientific databases were searched to retrieve studies depicting the biological activities of chalcones and their derivatives. This review comprehensively describes preclinical studies on chalcones and their derivatives describing their immense significance as antidiabetic, anticancer, anti-inflammatory, antimicrobial, antioxidant, antiparasitic, psychoactive, and neuroprotective agents. Besides, clinical trials revealed their use in the treatment of chronic venous insufficiency, skin conditions, and cancer. Bioavailability studies on chalcones and derivatives indicate possible hindrance and improvement in relation to its nutraceutical and pharmaceutical applications. Multifaceted and complex underlying mechanisms of chalcone actions demonstrated their ability to modulate a number of cancer cell lines, to inhibit a number of pathological microorganisms and parasites, and to control a number of signaling molecules and cascades related to disease modification. Clinical studies on chalcones revealed general absence of adverse effects besides reducing the clinical signs and symptoms with decent bioavailability. Further studies are needed to elucidate their structure activity, toxicity concerns, cellular basis of mode of action, and interactions with other molecules. © Copyright © 2021 Salehi, Quispe, Chamkhi, El Omari, Balahbib, Sharifi-Rad, Bouyahya, Akram, Iqbal, Docea, Caruntu, Leyva-Gómez, Dey, Martorell, Calina, López and Les.
Filiaciones:
Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Facultad de Ciencias de la Salud, Universidad Arturo Prat, Iquique, Chile
Faculty of Sciences, Mohammed V University of Rabat, Rabat, Morocco
Laboratory of Plant-Microbe Interactions, AgroBioSciences, Mohammed VI Polytechnic University, Ben Guerir, Morocco
Laboratory of Histology, Embryology, and Cytogenetic, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat, Morocco
Laboratory of Zoology and General Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, and Genomic Center of Human Pathologies, Faculty of Medicine and Pharmacy, Mohammed V University Rabat, Rabat, Morocco
Department of Eastern Medicine, Government College University, Faisalabad, Pakistan
Institute of Health Management, Dow University of Health Sciences, Karachi, Pakistan
Department of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Department of Physiology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Department of Dermatology, “Prof. N.C. Paulescu” National Institute of Diabetes, Nutrition, and Metabolic Diseases, Bucharest, Romania
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, Mexico
Department of Life Sciences, Presidency University, Kolkata, India
Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, Chile
Unidad De Desarrollo Tecnológico, UDT, Universidad De Concepción, Concepción, Chile
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, Zaragoza, Spain
Instituto Agroalimentario De Aragón-IA2 CITA-Universidad De Zaragoza, Zaragoza, Spain
Shahid Beheshti Univ Med Sci, Med Eth & Law Res Ctr, Tehran, Iran
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