Implementation of the emulsification-diffusion method by solvent displacement for polystyrene nanoparticles prepared from recycled material
Por:
Pineda-Reyes, Ana Maria, Hernandez Delgado, Mauricio, Zambrano-Zaragoza, Maria de la Luz, Leyva-Gomez, Gerardo, Mendoza-Munoz, Nestor, Quintanar-Guerrero, David
Publicada:
22 ene 2021
Resumen:
From an integral perspective, nanotechnology can be used to care for the
environment by improving current preparation methods and facilitating
industrial scale-up. This article discusses the implementation of
techniques for obtaining polystyrene nanoparticles (PSN), as an added
value, using an emulsification and solvent displacement method (EDSD);
the solvent displacement is a novel modification to the
emulsion-diffusion methodology, where the diffusion is done directly on
the emulsion, which allows concentrated dispersions that facilitate
direct use to be obtained, eliminating the dilution with water and the
recovery of water by additional processes. The solvent was recovered by
reduced pressure, which is class 3, conforming to ICH, and making this
method sustainable. The optimization of this process has not been
reported elsewhere. This approach made it possible to obtain
highly-concentrated nanoparticles while allowing the reuse of the
solvent. A scaling proposal is presented that integrates the
conditioning of the solid urban waste material called expanded
polystyrene (EPS) foam that constitutes a serious environmental problem
both nationally and globally. Hence, the article presents an alternative
to the recycling of EPS, and a methodology in the context of green
chemistry, because solvent is recovered to prepare other batches. The
PSN obtained from this waste material had a minimum particle size of
225.8 nm, with a polydispersion index of 0.158. Process performance was
97.1%, and the solvent was recovered at a maximum rate of 85%. The
morphology of the PSN was spherical and uniform, with a smooth surface.
Filiaciones:
Pineda-Reyes, Ana Maria:
Univ Nacl Autonoma Mexico, Lab Invest & Posgrad Tecnolog Farmaceut, Fac Estudios Super Cuautitlan, Ave 10 Mayo S-N, Cuautitlan 54740, Estado De Mexic, Mexico
Hernandez Delgado, Mauricio:
Univ Nacl Autonoma Mexico, Lab Invest & Posgrad Tecnolog Farmaceut, Fac Estudios Super Cuautitlan, Ave 10 Mayo S-N, Cuautitlan 54740, Estado De Mexic, Mexico
Zambrano-Zaragoza, Maria de la Luz:
Univ Nacl Autonoma Mexico, Lab Proc Transformac & Tecnol Emergentes Alimento, Fac Estudios Super Cuautitlan, Dept Ingn & Tecnol, Ave 10 Mayo S-N, Cuautitlan 54714, Estado De Mexic, Mexico
Leyva-Gomez, Gerardo:
Univ Nacl Autonoma Mexico, Dept Farm, Fac Quim, Mexico City 04510, DF, Mexico
Mendoza-Munoz, Nestor:
Univ Ciencias Quim, Fac Ciencias Quim, Colimas 28400, Mexico
Quintanar-Guerrero, David:
Univ Nacl Autonoma Mexico, Lab Invest & Posgrad Tecnolog Farmaceut, Fac Estudios Super Cuautitlan, Ave 10 Mayo S-N, Cuautitlan 54740, Estado De Mexic, Mexico
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