Monte Carlo dosimetry of a cell culture irradiation model using a 6 MV X-ray beam
Por:
Hernandez-Bojorquez, Mariana, Trejo-Solis, Cristina, Manuel Larraga-Gutierrez, Jose, Martinez-Davalos, Arnulfo
Publicada:
1 mar 2021
Categoría:
Radiation
Resumen:
We describe a cell culture irradiation model based on the use of a 6 MV
linear accelerator. The determination of dose delivered to the cell
culture relied upon a carefully validated Monte Carlo simulation of the
linear accelerator head, followed by radiation transport calculations of
relative dose on a model of the clonogenic assay, which included the
cell culture flask and supporting media. Absolute dose was determined by
cross calibration of the Monte Carlo model with ionization chamber
measurements along the central axis of a water phantom. An experimental
setup based on the irradiation model was used to obtain survival curves
of a human cell line of glioblastoma multiforme (U-373 MG). Our
measurements show excellent agreement with data previously reported in
the literature.
Filiaciones:
Hernandez-Bojorquez, Mariana:
Inst Politecn Nacl, Escuela Super Fis & Matemat, Edificio 9,Ave Inst Politecn Nacl, Mexico City 07738, DF, Mexico
Amer British Cowdray Med Ctr, Dept Radioterapia, Sur 136 116, Mexico City 01120, DF, Mexico
Trejo-Solis, Cristina:
Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, Dept Neuroinmunol, Insurgentes Sur 3877, Mexico City 14269, DF, Mexico
Manuel Larraga-Gutierrez, Jose:
Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, Lab Fis Med, Insurgentes Sur 3877, Mexico City 14269, DF, Mexico
Martinez-Davalos, Arnulfo:
Univ Nacl Autonoma Mexico, Inst Fis, AP 20-364, Mexico City 01000, DF, Mexico
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