Bisphenol A: an endocrine-disruptor compound that modulates the immune response to infections
Por:
Araiza V.H.D.R., Mendoza M.S., Castro K.E.N., Cruz S.M., Rueda K.C., de Leon C.T.G., Morales Montor, Jorge
Publicada:
1 ene 2021
Resumen:
Bisphenol A (BPA) is an endocrine-disruptor compound that exhibits
estrogenic activity. BPA is used in the production of materials such as
polycarbonate plastics, epoxy resins and dental sealants. Whereas, the
endocrine modulating activity of BPA and its effects on reproductive
health have been widely studied, its effects on the function of the
immune system are poorly characterized. This might be attributable to
the different BPA doses used in a diversity of animal models. Moreover,
most studies of the effect of BPA on the immune response are limited to
in vitro and in vivo studies that have focused primarily on the impact
of BPA on the number and proportion of immune cell populations, without
evaluating its effects on immune function in response to an antigenic
challenge or infectious pathogens. In this review, we discuss the
current literature on the effects of BPA on the function of immune
system that potentially increases the susceptibility to infections by
the virtue of acting as a pro-inflammatory molecule. Thus, it appears
that BPA, while by such an impact might be useful in the control of
certain disease states that are helped by an inflmmatory response, it
can worsen the prognosis of diseases that are adversely affected by
inflammation. GRAPHICS.
Filiaciones:
Departamento de Parasitologia, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, CP 04510, Mexico
Departamento de Farmacologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, CP 04510, Mexico
Laboratorio de Genotoxicologia y Mutagenesis Ambiental, Departamento de Ciencias Ambientales, Centro de Ciencias de la Atmosfera, Universidad Nacional Autonoma de Mexico CP 04510, Ciudad de Mexico, Mexico
Unidad de Investigacion Medica en Enfermedades Infecciosas y Parasitarias, UMAE Hospital de Pediatr�a, Centro Medico Siglo XXI, Instituto Mexicano del Seguro SocialMexico City 06720, Mexico
Unidad de Investigacion Medica en Enfermedades Infecciosas y Parasitarias, UMAE Hospital de Pediatria, Centro Medico Siglo XXI, Instituto Mexicano del Seguro SocialMexico City 06720, Mexico
Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, AP 70228, Ciudad de Mexico, CP 04510, Mexico
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