High prevalence of CYP2D6 ultrarapid metabolizers in a mestizo Colombian population in relation to Hispanic mestizo populations
Por:
Sarmiento, Alba P., Dorado, Pedro, Borbon, Angelica, de Andres, Fernando, LLerena, Adrian, Moya, Graciela E., Ferreiro, Veronica, Tarazona-Santos, Eduardo, Rodrigues-Soares, Fernanda, Barrantes, Ramiro, Jimenez-Arce, Gerardo, Cespedes-Garro, Carolina, Rodeiro, Idania, Delgado, Rene, Remirez, Diadelis, Calzadilla, Luis R., Teran, Enrique, Hernandez, Francisco, Teran, Santiago, Ortiz-Lopez, Rocio, Rojas-Martinez, Augusto, Perez-Paramo, Yadira X., Lopez-Lopez, Marisol, Ortega-Vazquez, Alberto, Monroy-Jaramillo, Nancy, Jung-Cook, Helgi, Fricke-Galindo, Ingrid, Sosa-Macias, Martha, Galaviz-Hernandez, Carlos, Lares-Aseff, Ismael, Lazalde-Ramos, Blanca P., Ramirez-Roa, Ronald, Tinoco, Catalina Altamirano, Grazina, Manuela, Penas-Lledo, Eva M., Cobaleda, Jesus, Farinas, Humberto, Estevez-Carrizo, Francisco E.
Publicada:
1 sep 2020
Resumen:
Background: Interethnic differences in CYP2D6 allele frequency have been
demonstrated across Latin-American countries. Only one previous study
describing CYP2D6 genotypes in Colombian population has been performed.
Thus, this study aimed to evaluate the CYP2D6 genetic variability in a
mestizo Colombian population, as well as the similarities and
differences concerning other Hispanic mestizo (HM) populations.
Methodology: Two hundred and twelve unrelated healthy Colombian subjects
were studied, in which different CYP2D6 polymorphisms were analyzed by
extra long-PCR and real-time PCR. Results/discussion: A high percentage
of ultrarapid metabolizers (18.4%) was found, representing the highest
frequency calculated within the HM populations studied. However, the
percentage of poor metabolizers (4.7%) was similar to those previously
reported in HM populations.
Filiaciones:
Pontificia Univ Javeriana, Bogota, Colombia
RIBEF Iberoamer Network Pharmacogenet & Pharmacog, Badajoz, Extremadura, Spain
Pontificia Univ Javeriana, PUJ, Bogota, Colombia
Univ Extremadura, INUBE Inst Univ Invest Biosanitaria Extremadura, Badajoz, Spain
Inst Univ Invest Biosanitaria Extremadura, INUBE, Badajoz, Spain
Univ Extremadura, Fac Med, UEX, Badajoz, Spain
Inst Nacl Salud, Bogota, Colombia
Inst Nacl Salud, INS, Bogota, Colombia
Inst Politecn Nacl CIIDIR, IPN, Durango, Mexico
Univ Nacl Autonoma Nicaragua, UNAN, Leon, Nicaragua
Serv Extremeno Salud, HUB SES, CICAB, Badajoz, Spain
Pontificia Univ Catolica Argentina, UCA, Buenos Aires, DF, Argentina
GENOS, Buenos Aires, DF, Argentina
Univ Fed Triangulo Mineiro, UFTM, Uberaba, Brazil
Univ Costa Rica, UCR, San Jose, Costa Rica
Inst Ciencias Mar, ICIMAR, Havana, Cuba
Ctr Invest & Desarrollo Medicamentos, CIDEM, Havana, Cuba
Ctr Control Estatal Calidad Medicamentos Equipos, CECMED, Havana, Cuba
Fac Ciencias Med Calixto Garcia ISCMLH, FCMCG, Havana, Cuba
Ctr Comunitario Salud Mental La Habana Vieja, CCSMLHV, Havana, Cuba
Univ San Francisco Quito, USFQ, Quito, Ecuador
Univ Guayaquil, UG, Guayaquil, Ecuador
Tecnol Monterrey, Monterrey, Nuevo Leon, Mexico
Washington State Univ, Spokane, WA 99202 USA
Univ Autonoma Metropolitana, UAM, Ciudad De Mexico, Mexico
Inst Nacl Neurol & Neurocirugla Manuel Velasco Su, INNNMVS, Ciudad De Mexico, Mexico
Univ Nacl Autonoma Mexico, UNAM, Ciudad De Mexico, Mexico
Univ Autonoma Zacatecas, UAZ, Zacatecas, Zacatecas, Mexico
Univ Coimbra, CNC Ctr Neurosci & Cell Biol, UC, Fac Med, Coimbra, Portugal
Univ Montevideo, UM, Montevideo, Uruguay
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