Choline acetyltransferase and TrkA expression, as well as the improvement in cognition produced by E2 and P4 in ovariectomized rats, are blocked by ICI 182780 and RU486
Por:
Espinosa-Raya, Judith, Cruz-Raya, Ulises, Lopez-Martinez, Margarita, Picazo, Ofir
Publicada:
1 ago 2018
Resumen:
Treatment with 17- estradiol and progesterone improves the performance
of ovariectomized rats in an autoshaping learning task, representing
cognitive improvement. To test whether this is attributable to genomic
mechanisms, the antiestrogen ICI 182780 or antiprogesterone RU486 was
injected into ovariectomized animals primed previously with estrogen or
progesterone, respectively. Compared with the vehicle control, each
hormone administered alone produced an elevated expression of choline
acetyltransferase and TrkA, along with an improvement in performance on
the behavioral test. E2+ICI reverted the increase in these two proteins.
However, RU alone elicited higher ChAT expression. With this exception,
there was a clear linear regression between the number of conditioned
responses and the level of ChAT and TrkA in the basal forebrain. The
results suggest that TrkA may be more important than ChAT for regulating
autoshaping learning tasks, and that genomic mechanisms in the basal
forebrain could possibly underlie hormonal improvement of cognition.
Filiaciones:
Espinosa-Raya, Judith:
Inst Politecn Nacl, Escuela Super Med, Mexico City 11340, DF, Mexico
Cruz-Raya, Ulises:
Inst Politecn Nacl, Escuela Super Med, Mexico City 11340, DF, Mexico
Lopez-Martinez, Margarita:
Inst Nacl Perinatol, Mexico City, DF, Mexico
Picazo, Ofir:
Inst Politecn Nacl, Escuela Super Med, Mexico City 11340, DF, Mexico
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