Activation of parvalbumin-expressing neurons reconfigures neuronal ensembles in murine striatal microcircuits
Por:
Duhne, Mariana, Lara-Gonzalez, Esther, Laville, Antonio, Padilla-Orozco, Montserrat, Avila-Cascajares, Fatima, Arias-Garcia, Mario, Galarraga, Elvira, Bargas, Jose
Publicada:
1 abr 2021
Ahead of Print:
1 ene 2020
Categoría:
Neuroscience (miscellaneous)
Resumen:
The striatum is the largest entrance to the basal ganglia. Diverse
neuron classes make up striatal microcircuit activity, consisting in the
sequential activation of neuronal ensembles. How different neuron
classes participate in generating ensemble sequences is unknown. In
control mus musculus brain slices in vitro, providing excitatory drive
generates ensemble sequences. In Parkinsonian microcircuits captured by
a highly recurrent ensemble, a cortical stimulus causes a transitory
reconfiguration of neuronal groups alleviating Parkinsonism. Alternation
between neuronal ensembles needs interconnectivity, in part due to
interneurons, preferentially innervated by incoming afferents. One main
class of interneuron expresses parvalbumin (PV+ neurons) and mediates
feed-forward inhibition. However, its more global actions within the
microcircuit are unknown. Using calcium imaging in ex vivo brain slices
simultaneously recording dozens of neurons, we aimed to observe the
actions of PV+ neurons within the striatal microcircuit. PV+ neurons in
active microcircuits are 5%-11% of the active neurons even if,
anatomically, they are <1% of the total neuronal population. In resting
microcircuits, optogenetic activation of PV+ neurons turns on circuit
activity by activating or disinhibiting, more neurons than those
actually inhibited, showing that feed-forward inhibition is not their
only function. Optostimulation of PV+ neurons in active microcircuits
inhibits and activates different neuron sets, resulting in the
reconfiguration of neuronal ensembles by changing their functional
connections and ensemble membership, showing that neurons may belong to
different ensembles at different situations. Our results show that PV+
neurons participate in the mechanisms that generate alternation of
neuronal ensembles, therefore provoking ensemble sequences.
Filiaciones:
Duhne, Mariana:
División Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Div Neurociencias, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
Lara-Gonzalez, Esther:
División Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico
Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico
Univ Nacl Autonoma Mexico, Div Neurociencias, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, Puebla, Mexico
Laville, Antonio:
División Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Div Neurociencias, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
Padilla-Orozco, Montserrat:
División Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Div Neurociencias, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
Avila-Cascajares, Fatima:
División Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Div Neurociencias, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
Arias-Garcia, Mario:
División Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Div Neurociencias, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
Galarraga, Elvira:
División Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Div Neurociencias, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
Bargas, Jose:
División Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico
Univ Nacl Autonoma Mexico, Div Neurociencias, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
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