High performance of rapid influenza diagnostic test and variable effectiveness of influenza vaccines in Mexico
Por:
Castillejos M., Cabello-Gutiérrez C., Alberto Choreño-Parra J., Hernández V., Romo J., Hernández-Sánchez F., Martínez D., Hernández A., Jiménez-Álvarez L., Hernández-Cardenas C.M., Becerril-Vargas E., Martínez-Orozco J.A., Luis Sandoval-Gutiérrez J., Guadarrama C., Olvera-Masetto E., Alfaro-Ramos L., Cruz-Lagunas A., Ramírez G., Márquez E., Pimentel L., Regino-Zamarripa N.E., Mendoza-Milla C., Goodina A., Hernández-Montiel E., Barquera R., Santibañez A., Domínguez-Cherit G., Pérez-Padilla R., Regalado J., Santillán-Doherty P., Salas-Hernández J., Zúñiga J.
Publicada:
1 ene 2019
Resumen:
Objectives: To evaluate the performance of rapid influenza diagnostic tests (RIDT) and influenza vaccines’ effectiveness (VE) during an outbreak setting. Methods: We compared the performance of a RIDT with RT-PCR for influenza virus detection in influenza-like illness (ILI) patients enrolled during the 2016/17 season in Mexico City. Using the test-negative design, we estimated influenza VE in all participants and stratified by age, virus subtype, and vaccine type (trivalent vs quadrivalent inactivated vaccines). The protective value of some clinical variables was evaluated by regression analyses. Results: We enrolled 592 patients. RT-PCR detected 93 cases of influenza A(H1N1)pdm09, 55 of AH3N2, 141 of B, and 13 A/B virus infections. RIDT showed 90.7% sensitivity and 95.7% specificity for influenza A virus detection, and 91.5% sensitivity and 95.3% specificity for influenza B virus detection. Overall VE was 33.2% (95% CI: 3.0–54.0; p = 0.02) against any laboratory-confirmed influenza infection. VE estimates against influenza B were higher for the quadrivalent vaccine. Immunization and occupational exposure were protective factors against influenza. Conclusions: The RIDT was useful to detect influenza cases during an outbreak setting. Effectiveness of 2016/17 influenza vaccines administered in Mexico was low but significant. Our data should be considered for future local epidemiological policies. © 2019 The Author(s)
Filiaciones:
Institutional Influenza Committee, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico
Department of Research in Virology and Mycology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico
Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico
Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, Mexico City, Mexico
Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico
Laboratory of Archeogenomics, Max Planck Institute, Gena, Germany
Critical Care Unit, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Dirección Médica, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico
Dirección General, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico
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