Cacalol Acetate, a Sesquiterpene from Psacalium decompositum, Exerts an Anti-inflammatory Effect through LPS/NF-KB Signaling in Raw 264.7 Macrophages
Por:
Mora-Ramiro, B., Jimenez-Estrada, M., Zentella-Dehesa, A., Ventura-Gallegos, J. L., Gomez-Quiroz, L. E., Rosiles-Alanis, W., Alarcon-Aguilar, F. J., Almanza-Perez, J. C.
Publicada:
28 ago 2020
Ahead of Print:
1 ene 2020
Resumen:
Inflammatory diseases remain critical health problems worldwide. The search for anti-inflammatory drugs is a primary activity in the pharmaceutical industry. Cacalol is a sesquiterpene with anti-inflammatory potential that is isolated from Psacalium decompositum, a medicinal plant with several scientific reports supporting its anti-inflammatory activity. Cacalol acetate (CA) is the most stable form. Nevertheless, the participation of CA in the main signaling pathway associated with inflammation is unknown. Our aim was to study the anti-inflammatory effect of CA and to determine its participation in NF-?B signaling. In TPA-induced edema in mice, CA produced 70.3% inhibition. To elucidate the influence of CA on the NF-?B pathway, RAW 264.7 macrophages were pretreated with CA and then stimulated with LPS, evaluating NF-?B activation, IKK phosphorylation, I?B-a, p65, cytokine expression, and COX-2 release and activity. CA inhibited NF-?B activation and its upstream signaling, decreasing phosphorylation IKB-a and p65 levels. CA also reduced expression and secretion of TNF-a, IL-1ß, and IL-6. Additionally, it decreased the activity and expression of COX-2 mRNA. These data support that CA regulates the NF-?B signaling pathway, which might explain, at least in part, its anti-inflammatory effect. CA is a bioactive molecule useful for the development of anti-inflammatory agents with innovative mechanisms of action. © 2020 American Chemical Society and American Society of Pharmacognosy.
Filiaciones:
Mora-Ramiro, B.:
Posgrado en Biología Experimental, Division de CBS, UAM-Iztapalapa., San Rafael Atlixco 186, Vicentina, Delegación Iztapalapa, C.P., Ciudad de México, 09340, Mexico
UAM Iztapalapa, Posgrad Biol Expt, Div CBS, Mexico City 09340, DF, Mexico
Jimenez-Estrada, M.:
Departamento de Productos Naturales, Instituto de Química, UNAM, Circuito, Mario de La Cueva s/n, C.U., Ciudad de México, 04510, Mexico
Univ Nacl Autonoma Mexico, Dept Prod Nat, Inst Quim, Mexico City 04510, DF, Mexico
Zentella-Dehesa, A.:
Programa Institucional de Cáncer de Mama, Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, UNAM, Circuito, Mario de La Cueva s/n, C.U., Ciudad de México, 04510, Mexico
Unidad de Bioquímica, Instituto de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Belisario Domínguez Secc 16, Tlalpan, Ciudad de México, 14080, Mexico
Univ Nacl Autonoma Mexico, Programa Inst Canc Mama, Dept Med Genom & Toxicol Ambiental, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Ventura-Gallegos, J. L.:
Programa Institucional de Cáncer de Mama, Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, UNAM, Circuito, Mario de La Cueva s/n, C.U., Ciudad de México, 04510, Mexico
Unidad de Bioquímica, Instituto de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Belisario Domínguez Secc 16, Tlalpan, Ciudad de México, 14080, Mexico
Univ Nacl Autonoma Mexico, Programa Inst Canc Mama, Dept Med Genom & Toxicol Ambiental, Inst Invest Biomed, Mexico City 04510, DF, Mexico
Inst Ciencias Med & Nutr Salvador Zubiran, Unidad Bioquim, Mexico City 14080, DF, Mexico
Gomez-Quiroz, L. E.:
Departamento de Ciencias de la Salud, CBS, UAM-Iztapalapa, San Rafael Atlixco 186, Vicentina, Delegación Iztapalapa, C.P., Ciudad de México, 09340, Mexico
UAM Iztapalapa, Dept Ciencias Salud, CBS, Mexico City, DF, Mexico
Rosiles-Alanis, W.:
Posgrado en Biología Experimental, Division de CBS, UAM-Iztapalapa., San Rafael Atlixco 186, Vicentina, Delegación Iztapalapa, C.P., Ciudad de México, 09340, Mexico
UAM Iztapalapa, Posgrad Biol Expt, Div CBS, Mexico City 09340, DF, Mexico
Alarcon-Aguilar, F. J.:
Laboratorio de Farmacología, Departamento de Ciencias de la Salud, División de CBS, UAM-Iztapalapa, San Rafael Atlixco 186, Vicentina, Delegación Iztapalapa, C.P., Ciudad de México, 09340, Mexico
UAM Iztapalapa, Lab Farmacol, Dept Ciencias Salud, Div CBS, Mexico City 09340, DF, Mexico
Almanza-Perez, J. C.:
Laboratorio de Farmacología, Departamento de Ciencias de la Salud, División de CBS, UAM-Iztapalapa, San Rafael Atlixco 186, Vicentina, Delegación Iztapalapa, C.P., Ciudad de México, 09340, Mexico
UAM Iztapalapa, Lab Farmacol, Dept Ciencias Salud, Div CBS, Mexico City 09340, DF, Mexico
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