Frequency of Defective Mismatch Repair System in a Series of Consecutive Cases of Colorectal Cancer in a National Cancer Center
Por:
López-Correa P.E., Lino-Silva L.S., Gamboa-Domínguez A., Zepeda-Najar C., Salcedo-Hernández R.A.
Publicada:
1 ene 2018
Resumen:
Background: The frequency of colorectal cancer (CRC) with defective mismatch repair (dMMR) is estimated between 5 and 15%. In our population, the frequency of dMMR is unknown. Our objective was to show the frequency of dMMR. Methods: Determination of dMMR with immunohistochemistry was performed prospectively for 202 patients who presented consecutively with CRC for the first time at our institution. Results: The median age was 59 years (IQR 47 to 68), 119 (58.9%) were women, and 43 (21.3%) cases showed dMMR. The only clinicopathological characteristics associated with dMMR were the location in the right colon and the presence of a family history of cancer. In the multivariate analysis, only the presence of the tumor in the right colon was associated with dMMR (OR = 5.823, 95%-C.I. = 2.653–12.784, p <.001). Conclusion: The 21.3% of the cases demonstrated a dMMR and the only clinical-pathological characteristic associated with dMMR was location in the right colon. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
Filiaciones:
Surgical Pathology, Instituto Nacional de Cancerología, Mexico City, Mexico
Surgical pathology, Fundación Universitaria de Ciencias de la Salud (FUCS), Hospital de San José, Bogotá, Colombia
Gastrointestinal Pathology Division, Instituto Nacional de Cancerología de México (Mexico’s National Cancer Institute), Av. San Fernando # 22, Sección XVI, Tlalpan, Mexico City, CP 14080, Mexico
Surgical Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Surgical Oncology, Hospital Ángeles Tijuana, Tijuana, Baja California Norte, Mexico
Surgical Oncology, Instituto Nacional de Cancerología, Mexico City, Mexico
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