Cortisol and DHEA-S levels in pregnant women with severe anxiety
Por:
Leff-Gelman, Philippe, Flores-Ramos, Monica, Avila Carrasco, Ariela Edith, Lopez Martinez, Margarita, Sarabia Takashima, Maria Fernanda, Cruz Coronel, Fausto Manuel, Farfan Labonne, Blanca, Zorrilla Dosal, Jose Antonio, Barriguete Chavez-Peon, Paola, Garza Morales, Saul, Camacho-Arroyo, Ignacio
Publicada:
5 ago 2020
Categoría:
Psychiatry and mental health
Resumen:
Background A complex interaction between cortisol and
dehydroepiandrosterone-sulphate (DHEA-S) is crucial in the stress system
balance; several studies have reported increased cortisol levels during
chronic stress and a weak counter-regulation by DHEA-S. During
pregnancy, scarce information about this system is available, although
cortisol and DHEA-S play an important role in the initiation and
acceleration of labor. We conducted the present study in order to
determine both cortisol and DHEA-S levels during the last trimester of
pregnancy in patients exhibiting severe anxiety. Methods Pregnant women
during the 3rd trimester of pregnancy were evaluated by using the
self-reported version of the Hamilton Anxiety Rating Scale (HARS).
According to the scores obtained from the psychometric scale,
participants were divided into two groups: 1) patients exhibiting a
cutoff score > 15 were considered with severe anxiety (ANX) (n = 101),
and control pregnant subjects (CTRL) (n = 44) with a cutoff score < 5.
Morning cortisol, DHEA-S and Cortisol/DHEA-S index were measured in all
participants. Comparisons between groups were performed; additionally,
correlations between clinical variables, biochemical data and HARS were
calculated. Results Cortisol levels were significantly higher in the ANX
group (p < 0.001), whereas those of DHEA-S were significantly lower in
the same group (p < 0.01) when compared to healthy pregnant subjects. An
increased cortisol/DHEA-S index was observed in the ANX group (p <
0.05). A significant association between cortisol and HARS scores (p =
0.03), was observed even after adjusting by gestational weeks (p =
0.004). Conclusions Our data support that the cortisol/DHEA-S index is
higher in pregnant women with high anxiety levels as compared with
healthy pregnant women.
Filiaciones:
Leff-Gelman, Philippe:
Inst Nacl Perinatol, Cdmx Mexico City 11000, Mexico
Flores-Ramos, Monica:
Inst Nacl Psiquiatria, Cdmx Mexico City 14370, Mexico
Consejo Nacl Ciencia & Tecnol CONACyT, Cdmx Mexico City 03940, Mexico
Avila Carrasco, Ariela Edith:
Inst Nacl Perinatol, Cdmx Mexico City 11000, Mexico
Lopez Martinez, Margarita:
Inst Nacl Perinatol, Cdmx Mexico City 11000, Mexico
Sarabia Takashima, Maria Fernanda:
Hosp Gen Mexico City, Cdmx Mexico City 06720, Mexico
Cruz Coronel, Fausto Manuel:
Hosp Gen Mexico City, Cdmx Mexico City 06720, Mexico
Farfan Labonne, Blanca:
Inst Nacl Perinatol, Cdmx Mexico City 11000, Mexico
Zorrilla Dosal, Jose Antonio:
Inst Nacl Perinatol, Cdmx Mexico City 11000, Mexico
Barriguete Chavez-Peon, Paola:
Inst Nacl Perinatol, Cdmx Mexico City 11000, Mexico
Garza Morales, Saul:
Inst Nacl Perinatol, Cdmx Mexico City 11000, Mexico
Camacho-Arroyo, Ignacio:
Univ Nacl Autonoma Mexico, Unidad Invest Reprod Humana, Inst Nacl Perinatol, Fac Quim, Cdmx Mexico City 04510, Mexico
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