Role of ion channels during cell division
Por:
Rosendo-Pineda M.J., Moreno, Claudia M., Vaca, Luis
Publicada:
1 nov 2020
Resumen:
Ion channels are transmembrane proteins whose canonical function is the
transport of ions across the plasma membrane to regulate cell membrane
potential and play an essential role in neural communication, nerve
conduction, and muscle contraction. However, over the last few years,
non-canonical functions have been identified for many channels, having
active roles in phagocytosis, invasiveness, proliferation, among others.
The participation of some channels in cell proliferation has raised the
question of whether they may play an active role in mitosis. There are
several reports showing the participation of channels during interphase,
however, the direct participation of ion channels in mitosis has
received less attention. In this article, we summarize the current
evidence on the participation of ion channels in mitosis. We also
summarize some tools that would allow the study of ion channels and cell
cycle regulatory molecules in individual cells during mitosis.
Filiaciones:
Rosendo-Pineda M.J.:
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México. Ciudad Universitaria, Coyoacán, DF 04510, Mexico
Moreno, Claudia M.:
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195, United States
Vaca, Luis:
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México. Ciudad Universitaria, Coyoacán, DF 04510, Mexico
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195, United States
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