Marine Organisms from the Yucatan Peninsula (Mexico) as a Potential Natural Source of Antibacterial Compounds
Por:
Pech-Puch, Dawrin, Perez-Povedano, Mar, Gomez, Patricia, Martinez-Guitian, Marta, Lasarte-Monterrubio, Cristina, Carlos Vazquez-Ucha, Juan, Lourdes Novoa-Olmedo, Maria, Guillen-Hernandez, Sergio, Villegas-Hernandez, Harold, Bou, German, RODRIGUEZ, JAIME, Beceiro, Alejandro, JIMENEZ, CARLOS
Publicada:
1 jul 2020
Resumen:
A total of 51 sponges (Porifera) and 13 ascidians (Chordata) were
collected on the coast of the Yucatan Peninsula (Mexico) and extracted
with organic solvents. The resulting extracts were screened for
antibacterial activity against four multidrug-resistant (MDR) bacterial
pathogens: the Gram-negativeAcinetobacter baumannii,Klebsiella
pneumoniae, andPseudomonas aeruginosaand the Gram-positiveStaphylococcus
aureus. The minimum inhibitory concentrations (MICs) of the organic
extracts of each marine organism were determined using a broth
microdilution assay. Extracts of eight of the species, in particular
theAgelas citrinaandHaliclona (Rhizoniera) curacaoensis, displayed
activity against some of the pathogens tested. Some of the extracts
showed similar MIC values to known antibiotics such as penicillins and
aminoglycosides. This study is the first to carry out antimicrobial
screening of extracts of marine sponges and ascidians collected from the
Yucatan Peninsula. Bioassay-guided fractionation of the active extracts
from the spongesAmphimedon compressaandA. citrinadisplayed, as a
preliminary result, that an inseparable mixture of halitoxins and
amphitoxins and (-)-agelasine B, respectively, are the major compounds
responsible for their corresponding antibacterial activities. This is
the first report of the antimicrobial activity of halitoxins and
amphitoxins against major multidrug-resistant human pathogens. The
promising antibacterial activities detected in this study indicate the
coast of Yucatan Peninsula as a potential source of a great variety of
marine organisms worthy of further research.
Filiaciones:
Pech-Puch, Dawrin:
Univ A Coruna, AE CICA INIBIC, Fac Ciencias, Ctr Invest Cient Avanzadas CICA, La Coruna 15071, Spain
Univ A Coruna, AE CICA INIBIC, Fac Ciencias, Dept Quim, La Coruna 15071, Spain
Perez-Povedano, Mar:
Univ A Coruna, AE CICA INIBIC, Fac Ciencias, Ctr Invest Cient Avanzadas CICA, La Coruna 15071, Spain
Univ A Coruna, AE CICA INIBIC, Fac Ciencias, Dept Quim, La Coruna 15071, Spain
Gomez, Patricia:
Univ Nacl Autonoma Mexico, Inst Ciencias Mar & Limnol, Unidad Acad Ecol & Biodiversidad Acuat, Cdmx 04510, Mexico
Martinez-Guitian, Marta:
Complexo Hosp Univ A Coruna, Inst Invest Biomed AE CICA INIBIC, Serv Microbiol, La Coruna 15006, Spain
Lasarte-Monterrubio, Cristina:
Complexo Hosp Univ A Coruna, Inst Invest Biomed AE CICA INIBIC, Serv Microbiol, La Coruna 15006, Spain
Carlos Vazquez-Ucha, Juan:
Complexo Hosp Univ A Coruna, Inst Invest Biomed AE CICA INIBIC, Serv Microbiol, La Coruna 15006, Spain
Lourdes Novoa-Olmedo, Maria:
Complexo Hosp Univ A Coruna, Inst Invest Biomed AE CICA INIBIC, Serv Microbiol, La Coruna 15006, Spain
Guillen-Hernandez, Sergio:
Univ Autonoma Yucatan, Dept Biol Marina, Campus Ciencias Biol & Agr, Merida 97000, Yucatan, Mexico
Villegas-Hernandez, Harold:
Univ Autonoma Yucatan, Dept Biol Marina, Campus Ciencias Biol & Agr, Merida 97000, Yucatan, Mexico
Bou, German:
Complexo Hosp Univ A Coruna, Inst Invest Biomed AE CICA INIBIC, Serv Microbiol, La Coruna 15006, Spain
RODRIGUEZ, JAIME:
Univ A Coruna, AE CICA INIBIC, Fac Ciencias, Ctr Invest Cient Avanzadas CICA, La Coruna 15071, Spain
Univ A Coruna, AE CICA INIBIC, Fac Ciencias, Dept Quim, La Coruna 15071, Spain
Beceiro, Alejandro:
Complexo Hosp Univ A Coruna, Inst Invest Biomed AE CICA INIBIC, Serv Microbiol, La Coruna 15006, Spain
JIMENEZ, CARLOS:
Univ A Coruna, AE CICA INIBIC, Fac Ciencias, Ctr Invest Cient Avanzadas CICA, La Coruna 15071, Spain
Univ A Coruna, AE CICA INIBIC, Fac Ciencias, Dept Quim, La Coruna 15071, Spain
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