Autophagy as a Potential Therapy for Malignant Glioma
Por:
Escamilla-Ramirez, Angel, Castillo-Rodriguez, Rosa A., Zavala-Vega, Sergio, Jimenez-Farfan, Dolores, Anaya-Rubio, Isabel, Briseno, Eduardo, Palencia, Guadalupe, GUEVARA, PATRICIA, Cruz-Salgado, Arturo, Sotelo, Julio, Trejo-Solis, Cristina
Publicada:
1 jul 2020
Resumen:
Glioma is the most frequent and aggressive type of brain neoplasm, being
anaplastic astrocytoma (AA) and glioblastoma multiforme (GBM), its most
malignant forms. The survival rate in patients with these neoplasms is
15 months after diagnosis, despite a diversity of treatments, including
surgery, radiation, chemotherapy, and immunotherapy. The resistance of
GBM to various therapies is due to a highly mutated genome; these
genetic changes induce a de-regulation of several signaling pathways and
result in higher cell proliferation rates, angiogenesis, invasion, and a
marked resistance to apoptosis; this latter trait is a hallmark of
highly invasive tumor cells, such as glioma cells. Due to a defective
apoptosis in gliomas, induced autophagic death can be an alternative to
remove tumor cells. Paradoxically, however, autophagy in cancer can
promote either a cell death or survival. Modulating the autophagic
pathway as a death mechanism for cancer cells has prompted the use of
both inhibitors and autophagy inducers. The autophagic process, either
as a cancer suppressing or inducing mechanism in high-grade gliomas is
discussed in this review, along with therapeutic approaches to inhibit
or induce autophagy in pre-clinical and clinical studies, aiming to
increase the efficiency of conventional treatments to remove glioma
neoplastic cells.
Filiaciones:
Escamilla-Ramirez, Angel:
Inst Nacl Neurol & Neurocirug, Dept Neuroinmunol, Mexico City 14269, DF, Mexico
Castillo-Rodriguez, Rosa A.:
CONACYT Inst Nacl Pediat, Lab Oncol Expt, Mexico City 04530, DF, Mexico
Zavala-Vega, Sergio:
Inst Nacl Neurol & Neurocirug, Dept Patol, Mexico City 14269, DF, Mexico
Jimenez-Farfan, Dolores:
Univ Nacl Autonoma Mexico, Lab Inmunol, Div Estudios Posgrad & Invest, Fac Odontol, Mexico City 04510, DF, Mexico
Anaya-Rubio, Isabel:
Inst Nacl Neurol & Neurocirug, Dept Neuroinmunol, Mexico City 14269, DF, Mexico
Briseno, Eduardo:
Inst Nacl Neurol & Neurocirug, Clin Neurooncol, Mexico City 14269, DF, Mexico
Palencia, Guadalupe:
Inst Nacl Neurol & Neurocirug, Dept Neuroinmunol, Mexico City 14269, DF, Mexico
GUEVARA, PATRICIA:
Inst Nacl Neurol & Neurocirug, Dept Neuroinmunol, Mexico City 14269, DF, Mexico
Cruz-Salgado, Arturo:
Inst Nacl Neurol & Neurocirug, Dept Neuroinmunol, Mexico City 14269, DF, Mexico
Sotelo, Julio:
Inst Nacl Neurol & Neurocirug, Dept Neuroinmunol, Mexico City 14269, DF, Mexico
Trejo-Solis, Cristina:
Inst Nacl Neurol & Neurocirug, Dept Neuroinmunol, Mexico City 14269, DF, Mexico
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