HCN2 activation modulation: An electrophysiological and molecular study of the well-preserved LCI sequence in the pore channel


Por: Hernandez, Adan, Hernandez-Centeno, Ricardo, Espino-Saldana, Angeles E., Martinez-Torres, Ataulfo

Publicada: 15 ago 2020
Resumen:
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels belong to the superfamily of voltage-gated potassium (Kv) and cyclic nucleotide-gated (CNG) channels. HCN channels contain the glycine-tyrosine-glycine (GYG) sequence that forms part of the selectivity filter, a similar structure than some potassium channels; however, they permeate both sodium and potassium, giving rise to an inward current. Yet a second amino acid sequence, leucine-cysteine-isoleucine (LCI), next to GYG, is well-preserved in all HCNs but not in the selective potassium channels. In this study we used site-directed mutagenesis and electrophysiology in frog oocytes to determine whether the LCI sequence affects the kinetics of HCN2 currents. Permeability and voltage dependence were evaluated, and we found a role of LCI in the gating mechanism combined with changes in ion permeability. The I residue resulted critical to this function.

Filiaciones:
Hernandez, Adan:
 Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Celular & Mol, Lab Neurobiol Mol & Celular, Santiago De Queretaro 76230, Queretaro, Mexico

Hernandez-Centeno, Ricardo:
 Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Celular & Mol, Lab Neurobiol Mol & Celular, Santiago De Queretaro 76230, Queretaro, Mexico

Espino-Saldana, Angeles E.:
 Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Celular & Mol, Lab Neurobiol Mol & Celular, Santiago De Queretaro 76230, Queretaro, Mexico

Martinez-Torres, Ataulfo:
 Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Celular & Mol, Lab Neurobiol Mol & Celular, Santiago De Queretaro 76230, Queretaro, Mexico
ISSN: 00039861





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Tipo de documento: Article
Volumen: 689 Número:
Páginas:
WOS Id: 000549359300013
ID de PubMed: 32492375

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