Efficiency comparison of experimental fosfatriclaben with three commercial fasciolicides in experimentally infected sheep
Por:
Arias-Garcia, Rosa, Vera-Montenegro, Yolanda, Flores-Ramos, Miguel, CASTILLO, RAFAEL, Hernandez-Campos, Alicia, Ibarra-Velarde, Froylan
Publicada:
1 ago 2020
Resumen:
In this work, we compare and evaluate the efficiency of fosfatriclaben
with three commercial fasciolicides in experimentally infected sheep.
Fosfatriclaben is a novel prodrug derived from triclabendazole; it is
highly water-soluble with excellent aqueous stability at pH 7,
properties that make it ideal for developing intramuscular
pharmaceutical compositions in the form of solutions. In order to
compare, 30 mixed breed sheep, previously diagnosed negative to fluke
eggs, were infected with 200 metacercariae of Fasciola hepatica, twice.
Five groups of six animals/each were formed for treatments. Group 1 (G1)
was treated with closantel 5% injectable at 5 mg/kg subcutaneously, G2
with clorsulon at 2 mg/kg subcutaneously, G3 with triclabendazole at 12
mg/kg per os, G4 with fosfatriclaben at 6 mg/kg intramuscularly (dose
equivalent to triclabendazole content), and G5 remained as the
non-treated control. On day 110, fecal samples were examined to
determine the percentage of egg reduction after treatment, and sheep
were humanely euthanized. The livers were collected, the flukes were
extracted, measured, and counted. Efficiency in egg reduction was of
86.8, 90.5, 98.4, and 97.3% for closantel, clorsulon, triclabendazole,
and fosfatriclaben, respectively, and efficiency against flukes was of
96.2, 91.9, 99.4, and 95.7%, respectively. No statistical differences
were found between treatments. It is concluded that fosfatriclaben at 6
mg/kg intramuscularly presented a high fasciolicide efficiency, similar
to the best commercial fasciolicides, having advantage over its
predecessor since it uses half of the dose required by triclabendazole
to remove flukes in sheep under study.
Filiaciones:
Univ Nacl Autonoma Mexico, Dept Parasitol, Fac Med Vet & Zootecnia, Mexico City 04510, DF, Mexico
Univ Nacl Autonoma Mexico, Dept Farm, Fac Quim, Mexico City 04510, DF, Mexico
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